VPS4B

Protein-coding gene in the species Homo sapiens

VPS4B

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1WR0, 1XWI, 2CPT, 2JQH, 2JQK, 4U7Y

Identifiers

Aliases

VPS4B, SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B

External IDs

OMIM: 609983; MGI: 1100499; HomoloGene: 37976; GeneCards: VPS4B; OMA:VPS4B - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q21.33	Start	63,389,190 bp^[1]
Band	18q21.33	End	63,422,483 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 E2.1	Start	106,691,801 bp^[2]
Band	1\|1 E2.1	End	106,724,458 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

amniotic fluid

epithelium of nasopharynx

secondary oocyte

gingival epithelium

mucosa of ileum

oral cavity

Achilles tendon

palpebral conjunctiva

hair follicle

Top expressed in

conjunctival fornix

ciliary body

Paneth cell

lacrimal gland

hair follicle

primitive streak

iris

vestibular sensory epithelium

medullary collecting duct

ureter

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding protein homodimerization activity ATPase activity protein C-terminus binding protein binding identical protein binding hydrolase activity ATP binding
Cellular component	cytoplasm cytosol endosome centrosome spindle pole membrane late endosome membrane Flemming body endosome membrane extracellular exosome nucleus
Biological process	late endosomal microautophagy regulation of centrosome duplication protein depolymerization viral budding via host ESCRT complex viral life cycle nucleus organization cholesterol transport negative regulation of exosomal secretion multivesicular body assembly negative regulation of cell death regulation of mitotic spindle assembly endosome organization cell division positive regulation of centriole elongation endosomal transport potassium ion transport response to lipid ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway protein transport ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway positive regulation of G2/M transition of mitotic cell cycle positive regulation of exosomal secretion septum digestion after cytokinesis mitotic metaphase plate congression endosome to lysosome transport via multivesicular body sorting pathway cell cycle ESCRT III complex disassembly macroautophagy transport positive regulation of viral process vacuole organization midbody abscission
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9525


20479

Ensembl


ENSG00000119541


ENSMUSG00000009907

UniProt


O75351


P46467

RefSeq (mRNA)


NM_004869


NM_009190

RefSeq (protein)


NP_004860 NP_004860.2


NP_033216

Location (UCSC)

Chr 18: 63.39 – 63.42 Mb

Chr 1: 106.69 – 106.72 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.^[5]^[6]

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.

In humans, two paralogs of the yeast protein have been identified. They share a high degree of amino acid sequence similarity with each other and also with yeast Vps4 and mouse proteins. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other (VPS4A) resides on chromosome 16.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009907 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
^ ^a ^b "Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)".

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Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
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Lambert C, Döring T, Prange R (2007). "Hepatitis B Virus Maturation Is Sensitive to Functional Inhibition of ESCRT-III, Vps4, and γ2-Adaptin". J. Virol. 81 (17): 9050–60. doi:10.1128/JVI.00479-07. PMC 1951427. PMID 17553870.