VRK2

Protein-coding gene in the species Homo sapiens
VRK2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2V62

Identifiers
AliasesVRK2, vaccinia related kinase 2, VRK serine/threonine kinase 2
External IDsOMIM: 602169; MGI: 1917172; HomoloGene: 55966; GeneCards: VRK2; OMA:VRK2 - orthologs
EC number2.7.11.1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for VRK2
Genomic location for VRK2
Band2p16.1Start57,907,629 bp[1]
End58,159,920 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for VRK2
Genomic location for VRK2
Band11|11 A3.3Start26,421,322 bp[2]
End26,543,999 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • Achilles tendon

  • gonad

  • corpus callosum

  • right ventricle

  • testicle

  • islet of Langerhans

  • epithelium of colon

  • epithelium of nasopharynx

  • rectum
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • mesenteric lymph nodes

  • blood

  • granulocyte

  • spleen

  • spermatocyte

  • thymus

  • morula

  • yolk sac

  • subcutaneous adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein domain specific binding
  • kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • protein kinase binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • endoplasmic reticulum membrane
  • mitochondrial membranes
  • membrane
  • endoplasmic reticulum
  • mitochondrion
  • nucleus
  • protein-containing complex
Biological process
  • regulation of MAPK cascade
  • regulation of interleukin-1-mediated signaling pathway
  • phosphorylation
  • protein phosphorylation
  • peptidyl-serine phosphorylation
  • protein autophosphorylation
  • cellular response to oxidative stress
  • viral process
  • regulation of cell shape
  • peptidyl-threonine phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7444

69922

Ensembl

ENSG00000028116

ENSMUSG00000064090

UniProt

Q86Y07

Q8BN21

RefSeq (mRNA)
NM_001130480
NM_001130481
NM_001130482
NM_001130483
NM_001288836

NM_001288837
NM_001288838
NM_001288839
NM_006296

NM_001252447
NM_027260

RefSeq (protein)
NP_001123952
NP_001123953
NP_001123954
NP_001123955
NP_001275765

NP_001275766
NP_001275767
NP_001275768
NP_006287

NP_001239376
NP_081536

Location (UCSC)Chr 2: 57.91 – 58.16 MbChr 11: 26.42 – 26.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.[5]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation.

While several transcript variants may exist for this gene, the full-length nature of only one has been biologically validated to date.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000028116 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064090 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: VRK2 vaccinia related kinase 2".

Further reading

  • Blanco S, Santos C, Lazo PA (2008). "Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1". Mol. Cell. Biol. 27 (20): 7273–83. doi:10.1128/MCB.00025-07. PMC 2168905. PMID 17709393.
  • Li LY, Liu MY, Shih HM, et al. (2006). "Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival". J. Gen. Virol. 87 (Pt 10): 2869–78. doi:10.1099/vir.0.81953-0. PMID 16963744.
  • Blanco S, Klimcakova L, Vega FM, Lazo PA (2006). "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines". FEBS J. 273 (11): 2487–504. doi:10.1111/j.1742-4658.2006.05256.x. hdl:10261/7155. PMID 16704422. S2CID 6110354.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nichols RJ, Traktman P (2004). "Characterization of three paralogous members of the Mammalian vaccinia related kinase family". J. Biol. Chem. 279 (9): 7934–46. doi:10.1074/jbc.M310813200. PMID 14645249.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nezu J, Oku A, Jones MH, Shimane M (1998). "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase". Genomics. 45 (2): 327–31. doi:10.1006/geno.1997.4938. PMID 9344656.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • v
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  • e
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K


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