WBP2

Protein-coding gene in the species Homo sapiens
WBP2
Identifiers
AliasesWBP2, WBP-2, GRAMD6, WW domain binding protein 2, DFNB107
External IDsOMIM: 606962; MGI: 104709; HomoloGene: 32160; GeneCards: WBP2; OMA:WBP2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for WBP2
Genomic location for WBP2
Band17q25.1Start75,845,699 bp[1]
End75,856,507 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for WBP2
Genomic location for WBP2
Band11|11 E2Start115,969,399 bp[2]
End115,977,821 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • right hemisphere of cerebellum

  • prefrontal cortex

  • C1 segment

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • cingulate gyrus

  • anterior cingulate cortex
Top expressed in
  • primary visual cortex

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • perirhinal cortex

  • cerebellar cortex

  • entorhinal cortex

  • right kidney

  • granulocyte

  • CA3 field
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • chromatin DNA binding
  • protein binding
  • RNA polymerase II core promoter sequence-specific DNA binding
  • transcription coactivator activity
  • estrogen receptor binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
  • nucleus
  • cytoplasm
Biological process
  • positive regulation of histone H3-K14 acetylation
  • positive regulation of transcription by RNA polymerase II
  • establishment of protein localization
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • cellular response to estrogen stimulus
  • response to progesterone
  • positive regulation of intracellular estrogen receptor signaling pathway
  • response to estrogen
  • progesterone receptor signaling pathway
  • transcription by RNA polymerase II
  • positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23558

22378

Ensembl

ENSG00000132471

ENSMUSG00000034341

UniProt

Q969T9

P97765

RefSeq (mRNA)

NM_012478
NM_001330499
NM_001348170

NM_016852
NM_001347642
NM_001361446

RefSeq (protein)

NP_001317428
NP_036610
NP_001335099

NP_001334571
NP_058548
NP_001348375

Location (UCSC)Chr 17: 75.85 – 75.86 MbChr 11: 115.97 – 115.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.[5][6]

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132471 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034341 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.
  6. ^ a b "Entrez Gene: WBP2 WW domain binding protein 2".

Further reading

  • Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
  • Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi:10.1074/jbc.272.27.17070. PMID 9202023.
  • Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nitsch R, Di Palma T, Mascia A, Zannini M (2004). "WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8". Biochem. J. 377 (Pt 3): 553–60. doi:10.1042/BJ20031233. PMC 1223889. PMID 14531730.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Dhananjayan SC, Ramamoorthy S, Khan OY, et al. (2006). "WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors". Mol. Endocrinol. 20 (10): 2343–54. doi:10.1210/me.2005-0533. PMID 16772533.


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