WDR68

Protein-coding gene in the species Homo sapiens
DCAF7
Identifiers
AliasesDCAF7, AN11, HAN11, SWAN-1, WDR68, DDB1 and CUL4 associated factor 7
External IDsOMIM: 605973; MGI: 1919083; HomoloGene: 55930; GeneCards: DCAF7; OMA:DCAF7 - orthologs
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[1]
Chromosome 11 (mouse)
Genomic location for DCAF7
Genomic location for DCAF7
Band11|11 E1Start105,927,698 bp[1]
End105,950,150 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • oocyte

  • secondary oocyte

  • renal medulla

  • cardia

  • trabecular bone

  • lower lobe of lung

  • ventral tegmental area

  • inferior ganglion of vagus nerve

  • subthalamic nucleus
Top expressed in
  • superior cervical ganglion

  • otolith organ

  • utricle

  • hand

  • Paneth cell

  • subiculum

  • trigeminal ganglion

  • anterior amygdaloid area

  • paraventricular nucleus of hypothalamus

  • arcuate nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • nuclear matrix
  • Cul4-RING E3 ubiquitin ligase complex
  • nucleus
  • cytoplasm
  • cytosol
  • nuclear body
  • nucleoplasm
  • protein-containing complex
Biological process
  • multicellular organism development
  • post-translational protein modification
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10238

71833

Ensembl

n/a

ENSMUSG00000049354

UniProt

P61962

P61963

RefSeq (mRNA)

NM_001003725
NM_005828

NM_027946

RefSeq (protein)

NP_005819

NP_082222

Location (UCSC)n/aChr 11: 105.93 – 105.95 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 68 is a protein that in humans is encoded by the DCAF7 gene.[4][5]

Interactions

WDR68 has been shown to interact with DYRK1A.[6]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049354 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ de Vetten N, Quattrocchio F, Mol J, Koes R (Jul 1997). "The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals". Genes Dev. 11 (11): 1422–34. doi:10.1101/gad.11.11.1422. PMID 9192870.
  5. ^ "Entrez Gene: WDR68 WD repeat domain 68".
  6. ^ Skurat AV, Dietrich AD (Jan 2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Morita K, Lo Celso C, Spencer-Dene B, Zouboulis CC, Watt FM (2006). "HAN11 binds mDia1 and controls GLI1 transcriptional activity". J. Dermatol. Sci. 44 (1): 11–20. doi:10.1016/j.jdermsci.2006.06.001. PMID 16887337.
  • Nissen RM, Amsterdam A, Hopkins N (2006). "A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression". BMC Dev. Biol. 6 (28): 28. doi:10.1186/1471-213X-6-28. PMC 1523201. PMID 16759393.
  • Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, Nissen RM (2010). "The zebrafish dyrk1b gene is important for endoderm formation". Genesis. 48 (1): 20–30. doi:10.1002/dvg.20578. PMC 2806492. PMID 20014342.
  • Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML (2010). "The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions". EMBO J. 29 (22): 3750–61. doi:10.1038/emboj.2010.251. PMC 2989105. PMID 20940704.


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