WFIKKN1

Protein-coding gene in the species Homo sapiens
WFIKKN1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DDI, 2DDJ

Identifiers
AliasesWFIKKN1, C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
External IDsOMIM: 608021; MGI: 2670967; HomoloGene: 14244; GeneCards: WFIKKN1; OMA:WFIKKN1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for WFIKKN1
Genomic location for WFIKKN1
Band16p13.3Start629,239 bp[1]
End634,117 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for WFIKKN1
Genomic location for WFIKKN1
Band17|17 A3.3Start26,096,602 bp[2]
End26,099,832 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • mucosa of transverse colon

  • right frontal lobe

  • pituitary gland

  • putamen

  • Brodmann area 9

  • anterior cingulate cortex

  • anterior pituitary

  • nucleus accumbens

  • skin of abdomen
Top expressed in
  • otic vesicle

  • primitive streak

  • embryo

  • somite

  • morula

  • tail of embryo

  • granulocyte

  • embryo

  • blastocyst

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • peptidase inhibitor activity
  • enzyme inhibitor activity
  • protein binding
  • metalloendopeptidase inhibitor activity
  • serine-type endopeptidase inhibitor activity
  • receptor antagonist activity
  • transforming growth factor beta binding
Cellular component
  • extracellular region
Biological process
  • skeletal system development
  • negative regulation of DNA binding
  • roof of mouth development
  • negative regulation of peptidase activity
  • negative regulation of protein binding
  • negative regulation of endopeptidase activity
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • extracellular negative regulation of signal transduction
  • negative regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

117166

215001

Ensembl

ENSG00000127578

ENSMUSG00000071192

UniProt

Q96NZ8

Q8R0S6

RefSeq (mRNA)

NM_053284

NM_001100454

RefSeq (protein)

NP_444514

NP_001093924

Location (UCSC)Chr 16: 0.63 – 0.63 MbChr 17: 26.1 – 26.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.[5][6][7] when found in humans.

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127578 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071192 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A. 98 (7): 3705–9. Bibcode:2001PNAS...98.3705T. doi:10.1073/pnas.061028398. PMC 31116. PMID 11274388.
  6. ^ Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. S2CID 37069938.
  7. ^ a b "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".

Further reading

  • Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein". J. Biomol. NMR. 35 (1): 73–8. doi:10.1007/s10858-006-9013-1. PMID 16791741. S2CID 34083234.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Nagy A, Trexler M, Patthy L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". Eur. J. Biochem. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
  • v
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  • 2ddi: NMR structure of the second Kunitz domain of human WFIKKN1
    2ddi: NMR structure of the second Kunitz domain of human WFIKKN1
  • 2ddj: NMR structure of the second Kunitz domain of human WFIKKN1
    2ddj: NMR structure of the second Kunitz domain of human WFIKKN1


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