ZNF473

Protein-coding gene in the species Homo sapiens
ZNF473
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EMB, 2EMC, 2EME, 2EOU, 2EOX, 2EOY, 2EOZ, 2YRH, 2YRJ, 2YSV, 2YTD, 2YTE, 2YTT, 2YU5

Identifiers
AliasesZNF473, HZFP100, ZN473, zinc finger protein 473, ZFP100
External IDsOMIM: 617908; MGI: 2442697; HomoloGene: 18698; GeneCards: ZNF473; OMA:ZNF473 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ZNF473
Genomic location for ZNF473
Band19q13.33Start50,025,714 bp[1]
End50,053,414 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ZNF473
Genomic location for ZNF473
Band7|7 B3Start44,380,904 bp[2]
End44,400,474 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • testicle

  • right testis

  • left testis

  • gonad

  • olfactory zone of nasal mucosa

  • sperm

  • anterior pituitary

  • ventricular zone

  • islet of Langerhans
Top expressed in
  • primary oocyte

  • secondary oocyte

  • zygote

  • urethra

  • otic vesicle

  • male urethra

  • tail of embryo

  • spermatocyte

  • epiblast

  • primitive streak
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • DNA binding
  • nucleic acid binding
  • protein binding
Cellular component
  • Cajal body
  • nucleus
  • intracellular anatomical structure
  • nucleoplasm
Biological process
  • termination of RNA polymerase II transcription
  • mRNA 3'-end processing by stem-loop binding and cleavage
  • regulation of transcription, DNA-templated
  • histone mRNA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25888

243963

Ensembl

ENSG00000142528

ENSMUSG00000048012

UniProt

Q8WTR7

Q8BI67

RefSeq (mRNA)

NM_001006656
NM_001308424
NM_015428

NM_001289836
NM_001289837
NM_001289838
NM_001289839
NM_178734

RefSeq (protein)

NP_001006657
NP_001295353
NP_056243

NP_001276765
NP_001276766
NP_001276767
NP_001276768
NP_848849

Location (UCSC)Chr 19: 50.03 – 50.05 MbChr 7: 44.38 – 44.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 473 is a protein that in humans is encoded by the ZNF473 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142528 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048012 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dominski Z, Erkmann JA, Yang X, Sanchez R, Marzluff WF (Jan 2002). "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing". Genes Dev. 16 (1): 58–71. doi:10.1101/gad.932302. PMC 155312. PMID 11782445.
  6. ^ "Entrez Gene: ZNF473 zinc finger protein 473".

Further reading

  • Wagner EJ, Marzluff WF (2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Mol. Cell. Biol. 26 (17): 6702–12. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Pillai RS, Grimmler M, Meister G, et al. (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev. 17 (18): 2321–33. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.


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