Zinc finger protein ZFPM1

Protein found in humans
ZFPM1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2XU7

Identifiers
AliasesZFPM1, FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A, zinc finger protein, FOG family member 1
External IDsOMIM: 601950; MGI: 1095400; HomoloGene: 7606; GeneCards: ZFPM1; OMA:ZFPM1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ZFPM1
Genomic location for ZFPM1
Band16q24.2Start88,453,280 bp[1]
End88,537,031 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for ZFPM1
Genomic location for ZFPM1
Band8|8 E1Start123,008,880 bp[2]
End123,063,990 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • mucosa of ileum

  • nasal epithelium

  • pylorus

  • cardia

  • parotid gland

  • ventral tegmental area

  • subthalamic nucleus

  • external globus pallidus

  • vena cava
Top expressed in
  • tibiofemoral joint

  • fetal liver hematopoietic progenitor cell

  • left lobe of liver

  • epithelium of stomach

  • pyloric antrum

  • internal carotid artery

  • external carotid artery

  • spleen

  • duodenum

  • human fetus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • transcription factor binding
  • metal ion binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • protein binding
  • nucleic acid binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • transcription regulator complex
  • transcription repressor complex
  • nucleoplasm
  • nucleus
Biological process
  • megakaryocyte development
  • megakaryocyte differentiation
  • negative regulation of mast cell differentiation
  • negative regulation of fat cell differentiation
  • regulation of transcription, DNA-templated
  • homeostasis of number of cells
  • ventricular septum morphogenesis
  • outflow tract morphogenesis
  • platelet formation
  • blood coagulation
  • cardiac muscle tissue morphogenesis
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of protein binding
  • transcription, DNA-templated
  • regulation of chemokine production
  • atrial septum morphogenesis
  • heart development
  • atrioventricular valve morphogenesis
  • granulocyte differentiation
  • embryonic hemopoiesis
  • regulation of definitive erythrocyte differentiation
  • T-helper cell lineage commitment
  • primitive erythrocyte differentiation
  • mitral valve formation
  • tricuspid valve formation
  • definitive erythrocyte differentiation
  • positive regulation of transcription by RNA polymerase II
  • erythrocyte differentiation
  • regulation of megakaryocyte differentiation
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

161882

22761

Ensembl

ENSG00000179588

ENSMUSG00000049577

UniProt

Q8IX07

O35615

RefSeq (mRNA)

NM_153813

NM_009569

RefSeq (protein)

NP_722520

NP_033595

Location (UCSC)Chr 16: 88.45 – 88.54 MbChr 8: 123.01 – 123.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG-1) is a protein that in humans is encoded by the ZFPM1 gene.[5] It is a cofactor of the GATA1 transcription factor.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179588 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049577 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZFPM1 zinc finger protein, multitype 1".

Further reading

  • Tsang AP, Visvader JE, Turner CA, et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation". Cell. 90 (1): 109–19. doi:10.1016/S0092-8674(00)80318-9. PMID 9230307. S2CID 2085524.
  • Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
  • Mehaffey MG, Newton AL, Gandhi MJ, et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1". Blood. 98 (9): 2681–8. doi:10.1182/blood.V98.9.2681. PMID 11675338.
  • Yu C, Niakan KK, Matsushita M, et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction". Blood. 100 (6): 2040–5. doi:10.1182/blood-2002-02-0387. PMC 2808424. PMID 12200364.
  • Freson K, Thys C, Wittewrongel C, et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions". Hum. Genet. 112 (1): 42–9. doi:10.1007/s00439-002-0832-1. PMID 12483298. S2CID 7394526.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Liew CK, Simpson RJ, Kwan AH, et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583–8. Bibcode:2005PNAS..102..583L. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.
  • Vannucchi AM, Pancrazzi A, Guglielmelli P, et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis". Am. J. Pathol. 167 (3): 849–58. doi:10.1016/S0002-9440(10)62056-1. PMC 1698737. PMID 16127162.
  • Yang HY, Kim SH, Kim SH, et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells". Biochem. Biophys. Res. Commun. 353 (4): 978–84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.
  • v
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  • e
  • 1srk: Solution structure of the third zinc finger domain of FOG-1
    1srk: Solution structure of the third zinc finger domain of FOG-1


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