CD44 |
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Structure de la protéine CD44. Basé sur l'identifiant PDB 1poz. |
Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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1POZ, 1UUH, 2I83, 4PZ3, 4PZ4 |
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Identifiants |
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Aliases | CD44 |
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IDs externes | OMIM: 107269 MGI: 88338 HomoloGene: 508 GeneCards: CD44 |
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Position du gène (Homme) |
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| Chr. | Chromosome 11 humain[1] |
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| Locus | 11p13 | Début | 35,138,882 bp[1] |
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Fin | 35,232,402 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 2 (souris)[2] |
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| Locus | 2 E2|2 54.13 cM | Début | 102,641,486 bp[2] |
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Fin | 102,732,010 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - parotide
- stromal cell of endometrium
- vulve
- gingival epithelium
- skin of thigh
- pénis humain
- skin of abdomen
- tendon calcanéen
- skin of hip
- îlot de Langerhans
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| Fortement exprimé dans | - molaire
- granulocyte
- calvaria
- derme
- glande submandibulaire
- epithelium of lens
- tibiofemoral joint
- parotide
- endothelial cell of lymphatic vessel
- corps du fémur
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| Plus de données d'expression de référence |
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BioGPS |
| Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - collagen binding
- liaison protéique
- hyaluronic acid binding
- cytokine receptor activity
- transmembrane signaling receptor activity
| Composant cellulaire | - integral component of membrane
- appareil de Golgi
- macrophage migration inhibitory factor receptor complex
- membrane
- focal adhesion
- membrane plasmique
- integral component of plasma membrane
- surface cellulaire
- exosome
- cytosol
- secretory granule membrane
- apical plasma membrane
- lamellipodium membrane
- prolongement cellulaire
- microvillosité
- basolateral plasma membrane
| Processus biologique | - negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- monocyte aggregation
- positive regulation of heterotypic cell-cell adhesion
- hyaluronan catabolic process
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- interferon-gamma-mediated signaling pathway
- extracellular matrix disassembly
- extracellular matrix organization
- negative regulation of apoptotic process
- cellular response to fibroblast growth factor stimulus
- positive regulation of peptidyl-serine phosphorylation
- cartilage development
- adhésion cellulaire
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of peptidyl-tyrosine phosphorylation
- cell-matrix adhesion
- positive regulation of monocyte aggregation
- leukocyte migration
- neutrophil degranulation
- wound healing, spreading of cells
- regulation of lamellipodium morphogenesis
- cell-cell adhesion
- réponse inflammatoire
- migration cellulaire
- T cell activation
- positive regulation of kinase activity
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392
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NM_001202555 NM_001202556 NM_001202557 |
| NM_001039150 NM_001039151 NM_001177785 NM_001177786 NM_001177787
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NM_009851 |
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RefSeq (protéine) | NP_000601 NP_001001389 NP_001001390 NP_001001391 NP_001001392
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NP_001189484 NP_001189485 NP_001189486 |
| NP_001034239 NP_001034240 NP_001171256 NP_001171257 NP_001171258
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NP_033981 |
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Localisation (UCSC) | Chr 11: 35.14 – 35.23 Mb | Chr 2: 102.64 – 102.73 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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