NRXN1 |
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PDBに登録されている構造 |
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PDB | オルソログ検索: RCSB PDBe PDBj |
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識別子 |
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記号 | NRXN1, Hs.22998, PTHSL2, SCZD17, neurexin 1 |
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外部ID | OMIM: 600565 MGI: 1096391 HomoloGene: 21005 GeneCards: NRXN1 |
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遺伝子の位置 (ヒト) |
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| 染色体 | 2番染色体 (ヒト)[1] |
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| バンド | データ無し | 開始点 | 49,918,503 bp[1] |
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終点 | 51,225,575 bp[1] |
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遺伝子の位置 (マウス) |
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| 染色体 | 17番染色体 (マウス)[2] |
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| バンド | データ無し | 開始点 | 90,033,631 bp[2] |
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終点 | 91,093,071 bp[2] |
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遺伝子オントロジー |
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分子機能 | • 金属イオン結合 • calcium-dependent protein binding • neuroligin family protein binding • 受容体結合 • 膜貫通シグナル伝達受容体活性 • cell adhesion molecule binding • 血漿タンパク結合 • type 1 fibroblast growth factor receptor binding • calcium ion binding • acetylcholine receptor binding • calcium channel regulator activity • シグナル伝達受容体活性
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細胞の構成要素 | • integral component of membrane • 小胞 • 核膜 • 膜 • endocytic vesicle • axonal growth cone • シナプス • cell surface • 細胞結合 • neuronal cell body • 小胞体 • presynaptic membrane • 細胞膜 • integral component of presynaptic membrane • presynapse • integral component of plasma membrane • 核小体 • 高分子複合体 • Schaffer collateral - CA1 synapse • glutamatergic synapse • GABA-ergic synapse • integral component of presynaptic active zone membrane
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生物学的プロセス | • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • receptor localization to synapse • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • NMDA glutamate receptor clustering • タンパク質局在化の確立 • neuron cell-cell adhesion • gamma-aminobutyric acid receptor clustering • neuronal signal transduction • gephyrin clustering involved in postsynaptic density assembly • postsynaptic density protein 95 clustering • 学習 • regulation of AMPA receptor activity • negative regulation of filopodium assembly • presynaptic membrane assembly • regulation of NMDA receptor activity • vocalization behavior • neuroligin clustering involved in postsynaptic membrane assembly • adult behavior • positive regulation of synaptic transmission, glutamatergic • postsynaptic membrane assembly • 細胞接着 • 血管新生 • positive regulation of excitatory postsynaptic potential • 社会的行動 • guanylate kinase-associated protein clustering • シナプス形成 • protein-containing complex assembly involved in synapse maturation • synaptic vesicle clustering • protein localization to synapse • シグナル伝達 • cerebellar granule cell differentiation • positive regulation of synapse assembly • positive regulation of presynaptic active zone assembly • positive regulation of protein localization to plasma membrane • positive regulation of gene expression • 遺伝子発現の負の調節 • positive regulation of protein kinase A signaling • neuron projection development • positive regulation of peptidyl-serine phosphorylation • positive regulation of fibroblast growth factor receptor signaling pathway • positive regulation of protein kinase B signaling • positive regulation of ERK1 and ERK2 cascade • cellular response to calcium ion • positive regulation of protein kinase C activity • vocal learning • 化学的シナプス伝達 • regulation of insulin secretion involved in cellular response to glucose stimulus • 軸索誘導 • プレパルス抑制 • neuromuscular process controlling balance • positive regulation of synapse maturation • neurotransmitter secretion • regulation of grooming behavior • synaptic membrane adhesion • regulation of synaptic vesicle cycle • regulation of postsynaptic specialization assembly • regulation of presynapse assembly • regulation of postsynaptic density assembly • trans-synaptic signaling by endocannabinoid
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出典:Amigo / QuickGO |
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オルソログ |
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種 | ヒト | マウス |
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Entrez | | |
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Ensembl | | |
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UniProt | |
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P58400,Q9ULB1,Q49A31,A4FVB9 |
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RefSeq (mRNA) | NM_001135659 NM_004801 NM_138735 NM_001320156 NM_001320157
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NM_001330077 NM_001330078 NM_001330079 NM_001330081 NM_001330082 NM_001330083 NM_001330084 NM_001330085 NM_001330086 NM_001330087 NM_001330088 NM_001330089 NM_001330090 NM_001330091 NM_001330092 NM_001330093 NM_001330094 NM_001330095 NM_001330096 NM_001330097 |
| NM_020252 NM_177284 NM_001346957 NM_001346958 NM_001346959
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NM_001346960 NM_001346961 NM_001346962 NM_001347419 |
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RefSeq (タンパク質) | NP_001129131 NP_001307085 NP_001307086 NP_001317006 NP_001317007
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NP_001317008 NP_001317010 NP_001317011 NP_001317012 NP_001317013 NP_001317014 NP_001317015 NP_001317016 NP_001317017 NP_001317018 NP_001317019 NP_001317020 NP_001317021 NP_001317022 NP_001317023 NP_001317024 NP_001317025 NP_001317026 NP_004792 NP_620072 NP_001129131.1 NP_004792.1 NP_620072.1 NP_004792.1 NP_004792.1 NP_620072.1 |
| NP_001333886 NP_001333887 NP_001333888 NP_001333889 NP_001333890
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NP_001333891 NP_001334348 NP_064648 NP_796258 NP_001390248 NP_001390249 NP_001390250 NP_001390251 NP_001390252 NP_001390253 NP_001390254 NP_001390255 NP_001390256 NP_001390257 NP_001390258 NP_001390259 NP_001390260 NP_001390261 NP_064648.3 NP_796258.2 |
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場所 (UCSC) | Chr 2: 49.92 – 51.23 Mb | Chr 2: 90.03 – 91.09 Mb |
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PubMed検索 | [3] | [4] |
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ウィキデータ |
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