CDK5

CDK5
Estruturas disponíveis PDB Pesquisa Human UniProt: PDBe RCSB Lista de códigos id do PDB 1H4L, 1UNG, 1UNH, 1UNL, 3O0G, 4AU8
Identificadores
Nomes alternativos	CDK5, quinase 5 dependente de ciclina
IDs externos	OMIM: 123831 HomoloGene: 3623 GeneCards: CDK5
Doenças Geneticamente Relacionadas
lissencephaly 7 with cerebellar hypoplasia[1]
Targeted by Drug
dinaciclib, dinaciclib, at-7519, AZD5438, rgb-286638 free base[2]
Ontologia genética Função molecular • acetylcholine receptor activator activity • kinase activity • cytoskeletal protein binding • ATP binding • protein kinase activity • protein serine/threonine kinase activity • ErbB-3 class receptor binding • transferase activity • ephrin receptor binding • tau-protein kinase activity • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • protein kinase binding • nucleotide binding • p53 binding • ErbB-2 class receptor binding • cyclin-dependent protein serine/threonine kinase activity • microtubule binding • tau protein binding • Hsp90 protein binding • voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Componente celular • postsynaptic membrane • membrane • sinapse • citoesqueleto • cell projection • lamellipodium • soma • filopodium • growth cone • junção neuromuscular • membrana plasmática • axónio • neuronal cell body • GO:0097483, GO:0097481 postsynaptic density • junção celular • dendrito • protein kinase 5 complex • presynapse • cariolinfa • núcleo celular • citoplasma • citosol • microtúbulo • neuron projection • Schaffer collateral - CA1 synapse • postsynapse • glutamatergic synapse Processo biológico • synaptic transmission, glutamatergic • rhythmic process • negative regulation of cell cycle • oligodendrocyte differentiation • synaptic transmission, dopaminergic • protein phosphorylation • positive regulation of neuron apoptotic process • central nervous system neuron development • regulation of synaptic vesicle recycling • ciclo celular • regulated exocytosis • corpus callosum development • Proliferação celular • intracellular protein transport • neuron projection development • regulation of dendritic spine morphogenesis • negative regulation of synaptic plasticity • cerebellar cortex formation • exocitose • response to cocaine • GO:0097285 apoptose • regulation of apoptotic process • negative regulation of proteolysis • behavioral response to cocaine • synaptic vesicle exocytosis • receptor clustering • positive regulation of calcium ion-dependent exocytosis • telencephalon development • synaptic vesicle endocytosis • response to wounding • regulation of postsynaptic membrane potential • potencial pós-sináptico excitatório • Sinaptogênese • protein autophosphorylation • positive regulation of actin cytoskeleton reorganization • negative regulation of neuron death • chemical synaptic transmission • neuron apoptotic process • neuron projection morphogenesis • associative learning • dendrite morphogenesis • fosforilação • calcium ion import • Schwann cell development • neuron migration • cerebellum development • nervous system development • regulation of synaptic plasticity • diferenciação neural • cerebral cortex development • axon extension • nocicepção • positive regulation of protein binding • cell-matrix adhesion • peptidyl-threonine phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of axon extension • GO:0033109 cortical actin cytoskeleton organization • protein localization to synapse • positive regulation of protein targeting to membrane • positive regulation of protein kinase activity • visual learning • regulation of cell migration • axonogenesis • positive regulation of neuron death • receptor catabolic process • divisão celular • negative regulation of protein ubiquitination • positive regulation of signaling receptor activity • negative regulation of protein export from nucleus • layer formation in cerebral cortex • GO:0035404 peptidyl-serine phosphorylation • nucleocytoplasmic transport • cerebellar cortex development • forebrain development • motor neuron axon guidance • Migração celular • skeletal muscle tissue development • hippocampus development • regulation of macroautophagy • regulation of signal transduction by p53 class mediator • serine phosphorylation of STAT protein • microtubule cytoskeleton organization • positive regulation of protein phosphorylation • mitochondrion organization • positive regulation of glial cell apoptotic process • synaptic vesicle transport • regulation of synaptic transmission, glutamatergic • synapse pruning • positive regulation of presynaptic cytosolic calcium concentration • induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration • regulation of protein localization to plasma membrane • cellular response to amyloid-beta Sources:Amigo / QuickGO
Padrão de expressão RNA Mais dados de referência de expressão
Ortólogos Espécie Humano Rato Entrez 1020 n/a Ensembl ENSG00000164885 n/a UniProt Q00535 n/a RefSeq (mRNA) NM_001164410 NM_004935 n/a RefSeq (proteína) NP_001157882 NP_004926 n/a Localização (UCSC) n/a n/a Pesquisa PubMed [3] n/a
Wikidata
Ver/Editar Humano

A quinase 5 dependente de ciclina é uma proteína, e mais especificamente uma enzima, que é codificada pelo gene CDK5.^[4][5] A molécula pertence à família das quinases dependentes de ciclina.^[6] As quinases são enzimas que catalisam reações de fosforilação, processo que permite que o substrato ganhe um grupo fosfato doado por um composto orgânico conhecido como ATP.^[7] As fosforilações são de vital importância durante a glicólise, tornando as quinases uma parte essencial da célula devido ao seu papel no metabolismo, sinalização celular e muitos outros processos.^[8]

Estrutura

A Cdk5 é uma serina/treonina quinase dirigida por prolina, que foi identificada pela primeira vez como um membro da família CDK devido à sua estrutura semelhante à CDC2/CDK1 em humanos, uma proteína que desempenha um papel crucial na regulação do ciclo celular.^[9][10]

Doenças

Doenças associadas com CDK5 incluem Lisencefalia 7 Com Hipoplasia Cerebelar e Lisencefalia. Entre suas vias relacionadas estão o dano ao DNA e a resposta ao Ca2+ citosólico plaquetário elevado. Deficiência da proteína DJ-1 relacionada a Parkinson altera a sinalização de Cdk5 e induz a morte neuronal por reentrada aberrante do ciclo celular.^[11][12]

Referências

Leitura adicional

• Portal da genética