NPM1

Estruturas disponíveis

PDB

Pesquisa Human UniProt: PDBe RCSB

Lista de códigos id do PDB
2LLH, 2P1B, 2VXD

Identificadores

Nomes alternativos

NPM1

IDs externos

OMIM: 164040 HomoloGene: 81697 GeneCards: NPM1

Targeted by Drug

ceritinib^[1]

Ontologia genética
Função molecular	• ribosomal large subunit binding • protein homodimerization activity • ribosomal small subunit binding • unfolded protein binding • GO:0001105 transcription coactivator activity • protein kinase inhibitor activity • GO:0031493 histone binding • Tat protein binding • NF-kappaB binding • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • RNA binding • protein heterodimerization activity • nucleic acid binding • protein kinase binding • transcription factor binding • rRNA binding • protein N-terminus binding • chromatin binding
Componente celular	• citoplasma • membrane • focal adhesion • spindle pole centrosome • cariolinfa • centro organizador dos microtúbulos • nucléolo • citoesqueleto • núcleo celular • protein-DNA complex • granular component • centrossoma • citosol • large ribosomal subunit • small ribosomal subunit • nuclear speck • GO:0009327 complexo macromolecular • Partículas de ribonucleoproteínas heterogéneas
Processo biológico	• centrosome cycle • regulation of eIF2 alpha phosphorylation by dsRNA • positive regulation of cell cycle G2/M phase transition • negative regulation of centrosome duplication • regulation of centriole replication • response to stress • positive regulation of translation • GO:0061641 CENP-A containing chromatin assembly • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of NF-kappaB transcription factor activity • protein complex oligomerization • negative regulation of protein kinase activity by regulation of protein phosphorylation • regulation of endodeoxyribonuclease activity • regulation of endoribonuclease activity • ribosome assembly • intracellular protein transport • GO:0100026 reparo de ADN • GO:0072468 transdução de sinal • negative regulation of cell population proliferation • nucleosome assembly • GO:0022415 viral process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to UV • ribosomal large subunit export from nucleus • ribosomal small subunit export from nucleus • rRNA export from nucleus • cell volume homeostasis • nucleocytoplasmic transport • GO:0034613 protein localization • positive regulation of cell population proliferation • posttranscriptional regulation of gene expression • negative regulation of gene expression • regulation of centrosome duplication • positive regulation of centrosome duplication • cell growth • positive regulation of cellular biosynthetic process • positive regulation of protein ubiquitination • regulation of protein stability • ribosomal large subunit biogenesis • ribosomal small subunit biogenesis • negative regulation of apoptotic process • regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of protein kinase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of mRNA splicing, via spliceosome • protein stabilization • protein homooligomerization • regulation of cell cycle • positive regulation of protein localization to nucleolus • chromatin remodeling • regulation of mRNA stability involved in cellular response to UV
Sources:Amigo / QuickGO

Padrão de expressão RNA

Mais dados de referência de expressão

Ortólogos

Espécie

Humano

Rato

Entrez


4869


n/a

Ensembl


ENSG00000181163


n/a

UniProt


P06748


n/a

RefSeq (mRNA)

NM_001037738 NM_002520 NM_199185 NM_001355006 NM_001355009
NM_001355007 NM_001355010


n/a

RefSeq (proteína)

NP_001032827 NP_002511 NP_954654 NP_001341935 NP_001341938
NP_001341936 NP_001341939


n/a

Localização (UCSC)

n/a

Pesquisa PubMed

^[2]

n/a

Wikidata

Ver/Editar Humano

A nucleofosfomina (fosfoproteína nucleolar B23, numatrina ou NPM1) é uma proteína nucleolar ubiquamente expressada que transloca-se entre o núcleo celular e o citoplasma. Está implicada em múltiplas funções celulares, incluindo codificação proteica ribossomal e transporte, controle da duplicação do centrossomo e regulação do gene supressor de tumor ARF.

Mutações que relocam a NPM1 do núcleo para o citoplasma estão associadas com o desenvolvimento da leucemia mielóide aguda.^[3]

Referências

↑ «Drogas que interagem fisicamente com Nucleophosmin 1 ver/editar referências no wikidata»
↑ «Human PubMed Reference:»
↑ Schneider F; et al. (maio de 2009). «NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS)». Blood. 113 (21). pp. 5250–3 !CS1 manut: Uso explícito de et al. (link)

Leitura de apoio

Yun C, Wang Y, Mukhopadhyay D; et al. (2008). «Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.». J Cell Biol. 183 (4): 589–95. PMC 2582899. PMID 19015314. doi:10.1083/jcb.200807185 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Haindl M, Harasim T, Eick D; et al. (2008). «The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.». EMBO reports. 9 (3): 273–279. doi:10.1038/embor.2008.3 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Li L, Li HS, Pauza CD; et al. (2006). «Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.». Cell Res. 15 (11-12): 923–34. PMID 16354571. doi:10.1038/sj.cr.7290370 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Gjerset RA (2007). «DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer.». J. Mol. Histol. 37 (5-7): 239–51. PMID 16855788. doi:10.1007/s10735-006-9040-y
Chen W, Rassidakis GZ, Medeiros LJ (2006). «Nucleophosmin gene mutations in acute myeloid leukemia.». Arch. Pathol. Lab. Med. 130 (11): 1687–92. PMID 17076533 !CS1 manut: Nomes múltiplos: lista de autores (link)
Falini B, Nicoletti I, Bolli N; et al. (2007). «Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias.». Haematologica. 92 (4): 519–32. PMID 17488663. doi:10.3324/haematol.11007 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Fankhauser C, Izaurralde E, Adachi Y; et al. (1991). «Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element.». Mol. Cell. Biol. 11 (5): 2567–75. PMC 360026. PMID 2017166 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Venkatesh LK, Mohammed S, Chinnadurai G (1990). «Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization.». Virology. 176 (1): 39–47. PMID 2109912. doi:10.1016/0042-6822(90)90228-J !CS1 manut: Nomes múltiplos: lista de autores (link)
Cochrane AW, Perkins A, Rosen CA (1990). «Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function.». J. Virol. 64 (2): 881–5. PMC 249184. PMID 2404140 !CS1 manut: Nomes múltiplos: lista de autores (link)
Chan PK, Chan WY, Yung BY; et al. (1986). «Amino acid sequence of a specific antigenic peptide of protein B23.». J. Biol. Chem. 261 (30): 14335–41. PMID 2429957 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Zhang XX, Thomis DC, Samuel CE (1989). «Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin.». Biochem. Biophys. Res. Commun. 164 (1): 176–84. PMID 2478125. doi:10.1016/0006-291X(89)91699-9 !CS1 manut: Nomes múltiplos: lista de autores (link)
Hale TK, Mansfield BC (1990). «Nucleotide sequence of a cDNA clone representing a third allele of human protein B23.». Nucleic Acids Res. 17 (23). 10112 páginas. PMC 335249. PMID 2602120
Chan WY, Liu QR, Borjigin J; et al. (1989). «Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth.». Biochemistry. 28 (3): 1033–9. PMID 2713355. doi:10.1021/bi00429a017 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Li XZ, McNeilage LJ, Whittingham S (1989). «The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23.». Biochem. Biophys. Res. Commun. 163 (1): 72–8. PMID 2775293. doi:10.1016/0006-291X(89)92100-1 !CS1 manut: Nomes múltiplos: lista de autores (link)
Chan PK, Aldrich M, Cook RG, Busch H (1986). «Amino acid sequence of protein B23 phosphorylation site.». J. Biol. Chem. 261 (4): 1868–72. PMID 3944116 !CS1 manut: Nomes múltiplos: lista de autores (link)
Bocker T, Bittinger A, Wieland W; et al. (1995). «In vitro and ex vivo expression of nucleolar proteins B23 and p120 in benign and malignant epithelial lesions of the prostate.». Mod. Pathol. 8 (3): 226–31. PMID 7542384 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Dundr M, Leno GH, Hammarskjöld ML; et al. (1995). «The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein.». J. Cell. Sci. 108 ( Pt 8): 2811–23. PMID 7593322 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Miyazaki Y, Takamatsu T, Nosaka T; et al. (1995). «The cytotoxicity of human immunodeficiency virus type 1 Rev: implications for its interaction with the nucleolar protein B23.». Exp. Cell Res. 219 (1): 93–101. PMID 7628555. doi:10.1006/excr.1995.1209 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Szebeni A, Herrera JE, Olson MO (1995). «Interaction of nucleolar protein B23 with peptides related to nuclear localization signals.». Biochemistry. 34 (25): 8037–42. PMID 7794916. doi:10.1021/bi00025a009 !CS1 manut: Nomes múltiplos: lista de autores (link)
Kato S, Sekine S, Oh SW; et al. (1995). «Construction of a human full-length cDNA bank.». Gene. 150 (2): 243–50. PMID 7821789. doi:10.1016/0378-1119(94)90433-2 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Marasco WA, Szilvay AM, Kalland KH; et al. (1995). «Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells.». Arch. Virol. 139 (1-2): 133–54. PMID 7826206. doi:10.1007/BF01309460 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Valdez BC, Perlaky L, Henning D; et al. (1994). «Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23.». J. Biol. Chem. 269 (38): 23776–83. PMID 8089149 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)