11b-hidroksisteroid dehidrogenaza
| 11b-hidroksisteroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Dimer 11beta-hidroksisteroid dehidrogenaze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.146 | ||||||||
| CAS broj | 9041-46-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
11b-hidroksisteroid dehidrogenaza (EC 1.1.1.146, kortikosteroid 11beta-dehidrogenaza, beta-hidroksisteroidna dehidrogenaza, 11beta-hidroksi steroidna dehidrogenaza, kortikosteroidna 11-reduktaza, dehidrogenaza, 11beta-hidroksi steroid) je enzim sa sistematskim imenom 11beta-hidroksisteroid:NADP+ 11-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 11beta-hidroksisteroid + NADP+ 11-oksosteroid + NADPH + H+
Reference
- ↑ Agarwal, A.K., Monder, C., Eckstein, B. and White, P.C. (1989). „Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase”. J. Biol. Chem. 264: 18939-18943. PMID 2808402.
- ↑ Bush, I.E., Hunter, S.A. and Meigs, R.A. (1968). „Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver”. Biochem. J. 107: 239-258. PMID 4384445.
- ↑ Lakshmi, V. and Monder, C. (1988). „Purification and characterization of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex”. Endocrinology 123: 2390-2398. PMID 3139396.
- ↑ Phillips, D.M., Lakshmi, V. and Monder, C. (1989). „Corticosteroid 11β-dehydrogenase in rat testis”. Endocrinology 125: 209-216. PMID 2661206.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH 11beta-hydroxysteroid+dehydrogenase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
