Arahidonat 15-lipoksigenaza
Arahidonat 15-lipoksigenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.13.11.33 | ||||||||
CAS broj | 82249-77-2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Arahidonat 15-lipoksigenaza (EC 1.13.11.33, 15-lipoksigenaza, linoleinska kiselina omega6-lipoksigenaza, omega6 lipoksigenaza) je enzim sa sistematskim imenom arahidonat:kiseonik 15-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- arahidonat + O2 (5Z,8Z,11Z,13E)-(15S)-15-hidroperoksiikosa-5,8,11,13-tetraenoat
Produkt se brzo redukuje do korespondirajućeg 15S-hidroksi jedinjenja.
Reference
- ↑ Bryant, R.W., Bailey, J.M., Schewqe, T. and Rapoport, S.M. (1982). „Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid”. J. Biol. Chem. 257: 6050-6055. PMID 6804460.
- ↑ Narumiya, S. and Salmon, J.A. (1982). „Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes”. Methods Enzymol. 86: 45-48. PMID 6813644.
- ↑ Oliw, E.H. and Sprecher, H. (1989). „Metabolism of polyunsaturated fatty acids by an (n-6)-lipoxygenase associated with human ejaculates”. Biochim. Biophys. Acta 1002: 283-291. PMID 2496760.
- ↑ Shibata, D., Steczko, J., Dixon, F.E., Hermodson, M., Yasdanparast, R. and Axelrod, B. (1987). „Primary structure of soybean lipoxygenase-1”. J. Biol. Chem. 262: 10080-10085. PMID 3112136.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Vanjske veze
- MeSH Arachidonate+15-lipoxygenase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6