DNAJC14

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DnaJ (Hsp40) homolog, potfamilija C, član 14
Identifikatori
SimboliDNAJC14; DNAJ; DRIP78; HDJ3; LIP6
Vanjski IDOMIM: 606092 MGI: 1921580 HomoloGene: 12553 GeneCards: DNAJC14 Gene
Ontologija gena
Molekularna funkcija vezivanje proteina toplotnog šoka
vezivanje nesavijenog proteina
Celularna komponenta endoplazmatični retikulum
membrana endoplazmatičnog retikuluma
membrane
integralno sa membranom
Biološki proces proteinsko savijanje
proteinski transport
Ortolozi
VrstaČovekMiš
Entrez8540674330
EnsemblENSG00000135392ENSMUSG00000025354
UniProtQ6Y2X3Q921R4
RefSeq (mRNA)NM_032364.5NM_028873.4
RefSeq (protein)NP_115740.5NP_083149.3
Lokacija (UCSC)Chr 12:
56.21 - 56.22 Mb
Chr 10:
128.24 - 128.26 Mb
PubMed pretraga[1][2]

DnaJ homologna potfamilija C, član 14 je protein koji je kod ljudi kodiran DNAJC14 genom.[1][2][3]

Interakcije

Za DNAJC14 je pokazano da formira interakcije sa dopaminskim receptorom D1.[4]

Reference

  1. Bermak JC, Li M, Bullock C, Zhou QY (May 2001). „Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein”. Nat Cell Biol 3 (5): 492–8. DOI:10.1038/35074561. PMID 11331877. 
  2. Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (May 2002). „The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins”. Mol Med 8 (1): 56–64. PMC 2039936. PMID 11984006. 
  3. „Entrez Gene: DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14”. 
  4. Bermak, J C; Li M, Bullock C, Zhou Q Y (May 2001). „Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein”. Nat. Cell Biol. (England) 3 (5): 492–8. DOI:10.1038/35074561. ISSN 1465-7392. PMID 11331877. 

Literatura

  • Bermak JC, Zhou QY (2004). „Accessory proteins in the biogenesis of G protein-coupled receptors.”. Mol. Interv. 1 (5): 282–7. PMID 14993367. 
  • Leclerc PC, Auger-Messier M, Lanctot PM, et al. (2002). „A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling.”. Endocrinology 143 (12): 4702–10. DOI:10.1210/en.2002-220679. PMID 12446598. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Chen J, Huang Y, Wu H, et al. (2003). „Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain.”. J. Hum. Genet. 48 (5): 217–21. DOI:10.1007/s10038-003-0012-8. PMID 12768437. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
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Šaperoni/
proteinsko uvijanje
Hsp10/GroES (Faktor rane trudnoće)  Hsp27  Hsp47  HSP60/GroEL

Hsp40/DnaJ (A1, A2, A3, B1, B2, B11, B4, B6, B9, C1, C3, C5, C6, C7, C10, C11, C13, C14, C19)

Hsp70 (1A, 1B, 1L, 2, 4, 4L, 5, 6, 7, 8, 9, 12A, 14)

Hsp90 (α1, α2, β, ER, TRAP1)
Drugi
Alfa kristalin  Klusterin  Opstanak motornog neurona (SMN1, SMN2)
Sortiranje proteinaUbikvitin
E1 Enzim ubikvitinske aktivacije (UBA1, UBA2, UBA3, UBA5, UBA6, UBA7, ATG7, NAE1, SAE1)

E2 Ubikvitin-konjugujući enzim (A • B • C • D1, D2, D3 • E1, E2, E3 • G1, G2 • H • I • J1, J2 • K • L1, L2, L3, L4, L6 • M • N • O • Q1, Q2 • R1 (CDC34), R2 • S • V1, V2 • Z)

E3 Ubikvitin ligaza (VHL, Kalin, CBL, MDM2, FANCL, UBR1)

Deubikvitinirajući enzim: Ataksin 3 • USP6 • CYLD

ATG3 • BIRC6 • UFC1
Drugi
vidi još Poremećaji posttranslacionih modifikacija
B bsyn: dnk (repl, cycl, reco, repr)  tscr (fact, tcrg, nucl, rnat, rept, ptts)  tltn (risu, pttl, nexn)  dnab, rnab/runp  stru (domn, 1°, 2°, 3°, 4°)