Hijaluronoglukozaminidaza
| Hijaluronoglukozaminidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.2.1.35 | ||||||||
| CAS broj | 37326-33-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hijaluronoglukozaminidaza (EC 3.2.1.35, hijaluronidaza, hijaluronoglukozidaza, hondroitinaza, hondroitinaza I) je enzim sa sistematskim imenom hijaluronat 4-glikanohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Randomna hidroliza (1->4)-veza između N-acetil-beta-D-glukozamina i D-glukuronatnih ostataka u hijaluronatu
Ovaj enzim takođe hidrolizuje 1,4-beta-D-glikozidne veze između N-acetil-galaktozamina ili N-acetilgalaktozamin sulfata i glukuronske kiseline u hondroitinu, hondroitin 4- i 6-sulfatima, i dermatanu.
Reference
- ↑ Meyer, K., Hoffman, P. and Linker, A. (1960). „Hyaluronidases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 447-460.
- ↑ Rapport, M.M., Myer, K. and Linker, A. (1951). „Analysis of the products formed on hydrolysis of hyaluronic acid by testicular hyaluronidase”. J. Am. Chem. Soc. 73: 2416-2420.
- ↑ Weissmann, B. (1955). „The transglycosylative action of testicular hyaluronidase”. J. Biol. Chem. 216: 783-794. PMID 13271353.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Meyer, K., Hoffman, P. and Linker, A. (1960). „Hyaluronidases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 447-460.
Spoljašnje veze
- MeSH Hyaluronoglucosaminidase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
