Karnozinska sintaza
| Karnozinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.11 | ||||||||
| CAS broj | 9023-61-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Karnozinska sintaza (EC 6.3.2.11, karnozinska sintetaza, karnozin-anserinska sintetaza, homokarnozin-karnozinska sintetaza, karnozin-homokarnozinska sintetaza, L-histidin:beta-alanin ligaza (formira AMP)) je enzim sa sistematskim imenom L-histidin:beta-alanin ligaza (formira ADP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + L-histidin + beta-alanin ADP + fosfat + karnozin
Ova enzim formira ADP.
Reference
- ↑ Kalyankar, G.D. and Meister, A. (1959). „Enzymatic synthesis of carnosine and related β-alanyl and γ-aminobutyryl peptides”. J. Biol. Chem. 234: 3210-3218. PMID 14404206.
- ↑ Stenesh, J.J. and Winnick, T. (1960). „Carnosine-anserine synthetase of muscle. 4. Partial purification of the enzyme and further studies of β-alanyl peptide synthesis”. Biochem. J. 77: 575-581. PMID 16748858.
- ↑ Crush, K.G. (1970). „Carnosine and related substances in animal tissues”. Comp. Biochem. Physiol. 34: 3-30. PMID 4988625.
- ↑ Drozak, J., Veiga-da-Cunha, M., Vertommen, D., Stroobant, V. and Van Schaftingen, E. (2010). „Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)”. J. Biol. Chem. 285: 9346-9356. PMID 20097752.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Carnosine+synthase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
