Kisela hidrolaza

Kisela hidrolaza (lizozomalna kisela lipaza) je enzim koji deluje pri kiselim pH vrednostima. On se normalno nalazi u lizozomima, koji su kiseli iznutra. Kisele hidrolaze mogu da budu nukleaze, proteaze, glikozidaze, lipaze, fosfataze, sulfataze i fosfolipaze. Postoji oko 50 degradativnih enzima u lizozimima koji razlažu biološke materijale.[1]

Reference

  1. ↑ Molecular Cell Biology 6ed, Lodish et al.

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 
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Proteini: enzimi
Teme
Aktivno mesto  • Alosterna regulacija  • Mesto vezivanja  • Katalitički perfektan enzim  • Koenzim  • Kofaktor  • Kooperativnost  • EC broj  • Enzimska kataliza  • Inhibicija enzima  • Enzimska kinetika  • Lajnviver–Burk dijagram  • Mihaelis–Mentenova kinetika  • Spisak enzima
Tipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6