Menatetrenon
(IUPAC) ime | |||
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2-metil-3-[(2Z,6E,10E)-3,7,11,15-tetrametilheksadeka-2,6,10,14-tetraen-1-il]naftohinon | |||
Klinički podaci | |||
AHFS/Drugs.com | Internacionalno ime leka | ||
Identifikatori | |||
CAS broj | 863-61-6 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 5282367 | ||
UNII | 27Y876D139 ![]() | ||
KEGG[3] | D00100 ![]() | ||
Hemijski podaci | |||
Formula | C31H40O2 | ||
Mol. masa | 444,648 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Sinonimi | 3-metil-2-[(2Z,6E,10E)-3,7,11,15-tetrametilheksadeka-2,6,10,14-tetraenil]naftalen-1,4-dion | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | |||
Način primene | Oralno |
Menatetrenon (MK4) je menahinonsko jedinjenje koji se koristi kao hemostatički agens i kao dopunska terapija za bol uzrokovan osteoporozom. On je u prodaji za tu tretman osteoporoze u Japanu pod imenom Glakaj.
Menatetrenon jedna od devet formi vitamina K2.[4]
MK4 se formira konverzijom vitamina K1 u telu, testisima, pankreasu i arterijskim zidovima.[5] Mada biohemijski put transformacije vitamina K1 u MK4 nije potpuno razjašnjen, studije sugerišu da konverzija nije zavisna od bakterija u crevima.[6][7][8][9] Tkiva koja akumuliraju velike količine MK4 imaju veliki kapacitet konvertovanja dostupnog K1 u MK4.[10][11]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Iwamoto J, Takeda T, Sato Y (December 2006). „Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis”. Nutr. Rev. 64 (12): 509–17. DOI:10.1111/j.1753-4887.2006.tb00184.x. PMID 17274493. [mrtav link]
- ↑ Shearer, Shearer MJ; Newman P. (2008). „Metabolism and cell biology of vitamin K”. Thrombosis and Haemostasis: 530–547. DOI:10.1160/TH08-03-0147.
- ↑ Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria1”. Journal of Nutrition 128 (2): 220–223. PMID 9446847.
- ↑ Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW. (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID 9468334.
- ↑ Thijssen, HHW; Drittij-Reijnders MJ (1994). „Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4”. British Journal of Nutrition 72 (3): 415–425. DOI:10.1079/BJN19940043. PMID 7947656.
- ↑ Will, BH; Usui Y, Suttie JW (1992). „Comparative Metabolism and Requirement of Vitamin K in Chicks and Rats”. Journal of Nutrition 122 (12): 2354–2360. PMID 1453219.
- ↑ Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria”. Journal of Nutrition 128 (2): 220–223. PMID 9446847.
- ↑ Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID 9468334.
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- „Glakay” (PDF). Eisai Co.. November 2009. Arhivirano iz originala na datum 2012-01-21. Pristupljeno 10. 1. 2012.
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D2 (Ergosterol, Ergokalciferol#) • D3 (7-Dehidroholesterol, Previtamin D3, Holekalciferol, 25-hidroksiholekalciferol, Kalcitriol (1,25-dihidroksiholekalciferol), Kalcitronska kiselina) D4 (Dihidroergokalciferol) • D5 • D analozi (Alfakalcidol, Dihidrotakisterol, Kalcipotriol, Takalcitol, Parikalcitol) | |
Naftohinon • Filohinon (K1) • Menatetrenon (K2) • Menadion (K3) • Menadiol (K4) |
B1 (Tiamin#) • B2 (Riboflavin#) • B3 (Niacin, Nikotinamid#) • B5 (Pantotenska kiselina, Dekspantenol, Pantetin) • B6 (Piridoksin#, Piridoksal fosfat, Piridoksamin) B7 (Biotin) • B9 (Folna kiselina, Dihidrofolna kiselina, Folinska kiselina, L-metilfolat) • B12 (Cijanokobalamin, Hidroksokobalamin, Metilkobalamin, Kobalamid) • B13 (Orotična kiselina) • B20 (Karnitin) • Bp (Holin) | |
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