Purin-nukleozid fosforilaza
| Purin-nukleozid fosforilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Trimer purin-nukleozid fosforilaze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.4.2.1 | ||||||||
| CAS broj | 9030-21-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Purin-nukleozid fosforilaza (EC 2.4.2.1, inozinska fosforilaza, PNPase, PUNPI, PUNPII, inozin-guanozinska fosforilaza, nukleotidna fosfataza, purin dezoksinukleozidna fosforilaza, purin dezoksiribonukleozidna fosforilaza, purin nukleozidna fosforilaza, purin ribonukleozidna fosforilaza) je enzim sa sistematskim imenom purin-nukleozid:fosfat riboziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- purin nukleozid + fosfat purin + alfa-D-riboza 1-fosfat
Specifičnost ovog enzima nije kompletno određena.
Reference
- ↑ Agarwal, R.P. and Parks, R.E. (1969). „Purine nucleoside phosphorylase from human erythrocytes. IV. Crystallization and some properties”. J. Biol. Chem. 244: 644-647. PMID 5768862.
- ↑ Friedkin, M. and Kalckar, H. (1961). „Nucleoside phosphorylases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 237-255.
- ↑ Heppel, L.A. and Hilmoe, R.J. (1952). „Phosphorolysis and hydrolysis of purine ribosides from yeast”. J. Biol. Chem. 198: 683-694. PMID 12999785.
- ↑ Kalckar, H.M. (1947). „The enzymatic synthesis of purine ribosides”. J. Biol. Chem. 167: 477-486.
- ↑ Saunders, P.P., Wilson, B.A. and Saunders, G.F. (1969). „Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus”. J. Biol. Chem. 244: 3691-3697. PMID 4978445.
- ↑ Tsuboi, K.K. and Hudson, P.B. (1957). „Enzymes of the human erythrocyte. I. Purine nucleoside phosphorylase; isolation procedure”. J. Biol. Chem. 224: 879-887. PMID 13405917.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Friedkin, M. and Kalckar, H. (1961). „Nucleoside phosphorylases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 237-255.
Spoljašnje veze
- MeSH Purine-nucleoside+phosphorylase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
