GNAO1

Guanin nukleotid-vezujući protein (G protein), podjedinica koja aktivira polipeptid O
Identifikatori
Simboli GNAO1; DKFZp686O0962; G-ALPHA-o; GNAO
Vanjski ID OMIM: 139311 MGI: 95775 HomoloGene: 39203 GeneCards: GNAO1 Gene
Ontologija gena
Molekularna funkcija • nucleotidno vezivanje
• aktivnost GTPaze
• aktivnost receptorskog signalnog proteina
• GTP vezivanje
Biološki proces • kontrakcija mišića
• prenos signala
• signalni put G-protein spregnutog receptora
• signalni put dopaminskog receptora
• razvoj nervnog sistema
• vođenje aksona
• lokomotorno ponašanje
• regulacija kontrakcije srca
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2775 14681
Ensembl ENSG00000087258 ENSMUSG00000031748
UniProt P09471 Q543S2
RefSeq (mRNA) NM_020988 NM_010308
RefSeq (protein) NP_066268 NP_034438
Lokacija (UCSC) Chr 16:
54.78 - 54.95 Mb		 Chr 8:
96.7 - 96.86 Mb
PubMed pretraga [1] [2]

GNAO1, Guanin nukleotid-vezujući protein G(o), podjedinica alfa, je protein koji je kod čoveka kodiran GNAO1 genom.[1][2][3]

Interakcije

Za GNAO1 je bilo pokazano da interaguje sa RGS20,[4] RGS19,[5][6] RIC8A[7] i RGS5.[8][9]

Reference

  1. ^ Murtagh JJ Jr; Eddy R; Shows TB; Moss J; Vaughan M (1991). „Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16”. Mol Cell Biol. 11 (2): 1146—55. PMC 359797 Слободан приступ. PMID 1899283. 
  2. ^ Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S (2001). „Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels”. J Biol Chem. 276 (31): 28731—8. PMID 11395521. doi:10.1074/jbc.M104806200. 
  3. ^ „Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O”. 
  4. ^ Pagano, Mario; Jordan J Dedrick; et al. (2008). „Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways”. Cell. Signal. England. 20 (6): 1190—7. ISSN 0898-6568. PMID 18407463. doi:10.1016/j.cellsig.2008.02.008. 
  5. ^ De Vries, L; Elenko E; et al. (1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203—8. ISSN 0027-8424. PMC 26381 Слободан приступ. PMID 8986788. doi:10.1073/pnas.93.26.15203. 
  6. ^ Woulfe, D S; Stadel J M (1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. J. Biol. Chem. UNITED STATES. 274 (25): 17718—24. ISSN 0021-9258. PMID 10364213. doi:10.1074/jbc.274.25.17718. 
  7. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200. 
  8. ^ Chen, C; Zheng B; et al. (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. UNITED STATES. 272 (13): 8679—85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679. 
  9. ^ Zhou, J; Moroi K; et al. (2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. England. 68 (13): 1457—69. ISSN 0024-3205. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0. 

Literatura

  • Raymond JR; Mukhin YV; Gelasco A; et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2-3): 179—212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3. 
  • Coupry I, Duzic E, Lanier SM (1992). „Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go.”. J. Biol. Chem. 267 (14): 9852—7. PMID 1349607. 
  • Denker BM, Neer EJ, Schmidt CJ (1992). „Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.”. J. Biol. Chem. 267 (9): 6272—7. PMID 1556134. 
  • Yi F, Denker BM, Neer EJ (1991). „Structural and functional studies of cross-linked Go protein subunits.”. J. Biol. Chem. 266 (6): 3900—6. PMID 1899868. 
  • Tsukamoto T; Toyama R; Itoh H; et al. (1991). „Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.”. Proc. Natl. Acad. Sci. U.S.A. 88 (8): 2974—8. PMC 51366 Слободан приступ. PMID 1901650. doi:10.1073/pnas.88.8.2974. 
  • Gabrion J; Brabet P; Nguyen Than Dao B; et al. (1990). „Ultrastructural localization of the GTP-binding protein Go in neurons.”. Cell. Signal. 1 (1): 107—23. PMID 2518353. doi:10.1016/0898-6568(89)90025-9. 
  • Lavu S; Clark J; Swarup R; et al. (1988). „Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha.”. Biochem. Biophys. Res. Commun. 150 (2): 811—5. PMID 3124840. doi:10.1016/0006-291X(88)90463-9. 
  • Zumbihl R; Breuiller-Fouché M; Carrette J; et al. (1995). „Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium.”. Eur. J. Pharmacol. 288 (1): 9—15. PMID 7705473. 
  • Grassie MA, Milligan G (1995). „Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.”. Biochem. J. 306 (Pt 2): 525—30. PMC 1136549 Слободан приступ. PMID 7887906. 
  • Wu HC, Lin CT (1994). „Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.”. Lab. Invest. 71 (2): 175—81. PMID 8078296. 
  • Nitta K; Uchida K; Kawashima A; et al. (1994). „Identification of GTP-binding proteins in human glomeruli.”. Nippon Jinzo Gakkai shi. 36 (1): 9—12. PMID 8107314. 
  • Georgoussi Z, Carr C, Milligan G (1993). „Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go.”. Mol. Pharmacol. 44 (1): 62—9. PMID 8393523. 
  • Laugwitz KL; Allgeier A; Offermanns S; et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116—20. PMC 40189 Слободан приступ. PMID 8552586. doi:10.1073/pnas.93.1.116. 
  • Kawano N; Ito T; Kitamura H; et al. (1997). „Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasms.”. Pathol. Int. 46 (6): 393—8. PMID 8869990. doi:10.1111/j.1440-1827.1996.tb03629.x. 
  • De Vries L; Elenko E; Hubler L; et al. (1997). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.”. Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203—8. PMC 26381 Слободан приступ. PMID 8986788. doi:10.1073/pnas.93.26.15203. 
  • Valenzuela D; Han X; Mende U; et al. (1997). „G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart.”. Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1727—32. PMC 19984 Слободан приступ. PMID 9050846. doi:10.1073/pnas.94.5.1727. 
  • Chen C, Zheng B, Han J, Lin SC (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.”. J. Biol. Chem. 272 (13): 8679—85. PMID 9079700. doi:10.1074/jbc.272.13.8679. 
  • Natochin M, Lipkin VM, Artemyev NO (1997). „Interaction of human retinal RGS with G-protein alpha-subunits.”. FEBS Lett. 411 (2-3): 179—82. PMID 9271201. doi:10.1016/S0014-5793(97)00687-X. 
  • Busconi L, Denker BM (1998). „Analysis of the N-terminal binding domain of Go alpha.”. Biochem. J. 328 (Pt 1): 23—31. PMC 1218882 Слободан приступ. PMID 9359829. 
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Klasa A: Rodopsinu slični
Neurotransmiter
Adrenergički
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
Neuropeptidni
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
Orfan
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
Orfan
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
Ukus
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni