Kaspofungin
Klinički podaci | |
---|---|
Drugs.com | Monografija |
Način primene | Intravenozno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 9-11 h |
Izlučivanje | Fekalno 35%, renalno 41% |
Identifikatori | |
CAS broj | 179463-17-3 Y |
ATC kod | J02AX04 (WHO) |
PubChem | CID 2826718 |
DrugBank | DB00520 Y |
ChemSpider | 411774 Y |
ChEBI | CHEBI:474180 Y |
ChEMBL | CHEMBL499808 Y |
Hemijski podaci | |
Formula | C52H88N10O15 |
Molarna masa | 1093,313 |
SMILES
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InChI
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Kaspofungin je organsko jedinjenje, koje sadrži 52 atoma ugljenika i ima molekulsku masu od 1093,313 Da.[1][2][3][4][5][6][7][8]
Osobine
Osobina | Vrednost |
---|---|
Broj akceptora vodonika | 18 |
Broj donora vodonika | 16 |
Broj rotacionih veza | 23 |
Particioni koeficijent[9] (ALogP) | -2,9 |
Rastvorljivost[10] (logS, log(mol/L)) | -8,1 |
Polarna površina[11] (PSA, Å2) | 412,0 |
Reference
- ^ Letscher-Bru, V.; Herbrecht, R. (2003). „Caspofungin: The first representative of a new antifungal class”. Journal of Antimicrobial Chemotherapy. 51 (3): 513—521. PMID 12615851. doi:10.1093/jac/dkg117.
- ^ Sucher, A. J.; Chahine, E. B.; Balcer, H. E. (2009-09-01). „Echinocandins: The newest class of antifungals”. The Annals of Pharmacotherapy. 43 (10): 1647—57. PMID 19724014. S2CID 207263606. doi:10.1345/aph.1M237.
- ^ Morrison, V. A. (октобар 2005). „Caspofungin: An overview”. Expert Review of Anti-Infective Therapy. 3 (5): 697—705. PMID 16207161. S2CID 24716189. doi:10.1586/14787210.3.5.697. CS1 одржавање: Формат датума (веза)
- ^ McCormack, P. L.; Perry, C. M. (2005). „Caspofungin: A review of its use in the treatment of fungal infections”. Drugs. 65 (14): 2049—68. PMID 16162025. doi:10.2165/00003495-200565140-00009.
- ^ Morris, M. I.; Villmann, M. (2006-09-15). „Echinocandins in the management of invasive fungal infections, part 1”. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 63 (18): 1693—703. PMID 16960253. doi:10.2146/ajhp050464.p1.
- ^ Morris, M. I.; Villmann, M. (2006). „Echinocandins in the management of invasive fungal infections, Part 2”. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 63 (19): 1813—1820. PMID 16990627. doi:10.2146/ajhp050464.p2.
- ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. Текст „noedit ” игнорисан (помоћ)
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. Текст „noedit ” игнорисан (помоћ)
- ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. Текст „noedit ” игнорисан (помоћ)
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Caspofungin
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