Leukocitna elastaza

Leukocitna elastaza
Identifikatori
EC broj3.4.21.37
CAS broj2594837
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Pretraga
PMCčlanci
PubMedčlanci
NCBIproteini

Leukocitna elastaza (EC 3.4.21.37, lizozomalna elastaza, neutrofilna elastaza, polimorfonuklearna leukocitna elastaza, elastaza, elaszim, serinska elastaza, lizozomalna elastaza, granulocitna elastaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina, uključujući elastin. Preferentno odvajanje Val- > Ala-

Ovaj enzim se razlikuje od pankreasne elastaze po specifičnosti na sintetičim supstratima i po senzitivnosti na inhibitore.

Reference

  1. ^ Barrett, A.J. (1981). „Leukocyte elastase”. Methods Enzymol. 80: 581—588. PMID 7043201. 
  2. ^ Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C. (1984). „Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus' protease V-8 using tripeptide thiobenzyl ester substrates”. Biochemistry. 23: 2995—3002. PMID 6380580. CS1 одржавање: Вишеструка имена: списак аутора (веза)
  3. ^ Stein, R.L., Strimpler, A.M., Hori, H. and Powers, J.C. (1987). „Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements”. Biochemistry. 26: 1301—1305. PMID 3646070. CS1 одржавање: Вишеструка имена: списак аутора (веза)
  4. ^ Bode, W., Meyer, E., Jr. and Powers, J.C. (1989). „Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors”. Biochemistry. 28: 1951—1963. PMID 2655701. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
  • William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

  • Leukocyte+elastase на US National Library of Medicine Medical Subject Headings (MeSH)
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Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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