Racivir : Osobine, Reference, Literatura, Spoljašnje veze Википедија

Racivir

Racivir
Klinički podaci

Drugs.com	Monografija
Identifikatori
CAS broj	137530-41-7^Y
ATC kod	none
PubChem	CID 454858
Hemijski podaci
Formula	C₈H₁₀FN₃O₃S
Molarna masa	247,247
SMILES OC[C@H]1O[C@H](CS1)N2C=C(F)C(=N)N=C2O
InChI InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m1/s1^Y Key:XQSPYNMVSIKCOC-RITPCOANSA-N^Y

Racivir je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 247,247 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	7
Broj donora vodonika	3
Broj rotacionih veza	2
Particioni koeficijent^[1] (ALogP)	-0,6
Rastvorljivost^[2] (logS, log(mol/L))	-0,7
Polarna površina^[3] (PSA, Å²)	114,4

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.