MSX2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/5/57/Protein_MSX2_PDB_1ig7.png/250px-Protein_MSX2_PDB_1ig7.png) |
Ідентифікатори |
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Символи | MSX2, CRS2, FPP, HOX8, MSH, PFM, PFM1, Msh homeobox 2 |
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Зовнішні ІД | OMIM: 123101 MGI: 97169 HomoloGene: 1837 GeneCards: MSX2 |
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Пов'язані генетичні захворювання |
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Parietal foramina with cleidocranial dysplasia, parietal foramina[1] |
Онтологія гена |
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Молекулярна функція | • sequence-specific DNA binding • DNA binding • GO:0001104 transcription coregulator activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
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Клітинна компонента | • клітинне ядро • гіалоплазма • nuclear speck |
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Біологічний процес | • negative regulation of cell population proliferation • positive regulation of timing of catagen • negative regulation of keratinocyte differentiation • negative regulation of transcription regulatory region DNA binding • embryonic limb morphogenesis • frontal suture morphogenesis • mammary gland epithelium development • BMP signaling pathway involved in heart development • enamel mineralization • осифікація • anterior/posterior pattern specification • bone morphogenesis • GO:0009373 regulation of transcription, DNA-templated • cellular response to growth factor stimulus • activation of meiosis • endochondral bone growth • wound healing, spreading of epidermal cells • BMP signaling pathway • embryonic digit morphogenesis • positive regulation of mesenchymal cell apoptotic process • multicellular organism development • embryonic hindlimb morphogenesis • negative regulation of CREB transcription factor activity • outflow tract morphogenesis • bone trabecula formation • Загоєння ран • regulation of apoptotic process • chondrocyte development • osteoblast development • positive regulation of osteoblast differentiation • cranial suture morphogenesis • negative regulation of fat cell differentiation • branching involved in mammary gland duct morphogenesis • outflow tract septum morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • osteoblast differentiation • epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of BMP signaling pathway • signal transduction involved in regulation of gene expression • cellular response to estradiol stimulus • embryonic forelimb morphogenesis • embryonic nail plate morphogenesis • negative regulation of apoptotic process • cartilage development • stem cell differentiation • odontogenesis • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • embryonic morphogenesis |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/PBB_GE_MSX2_205555_s_at_fs.png/250px-PBB_GE_MSX2_205555_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/0/08/PBB_GE_MSX2_210319_x_at_fs.png/250px-PBB_GE_MSX2_210319_x_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 5: 174.72 – 174.73 Mb | н/д |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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