PAX6 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Protein_PAX6_PDB_2cue.png/250px-Protein_PAX6_PDB_2cue.png) |
Наявні структури |
---|
PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2CUE, 6PAX | | |
Ідентифікатори |
---|
Символи | PAX6, AN, AN2, D11S812E, FVH1, MGDA, WAGR, paired box 6, ASGD5 |
---|
Зовнішні ІД | OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6 |
---|
|
Пов'язані генетичні захворювання |
---|
Morning glory disc anomaly, aniridia type 2, foveal hypoplasia-presenile cataract syndrome[1] |
Онтологія гена |
---|
Молекулярна функція | • GO:0001948, GO:0016582 protein binding • DNA binding • sequence-specific DNA binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • protein kinase binding • ubiquitin protein ligase binding • histone acetyltransferase binding • co-SMAD binding • R-SMAD binding • HMG box domain binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
---|
Клітинна компонента | • цитоплазма • клітинне ядро • нуклеоплазма • гіалоплазма • внутрішньоклітинний |
---|
Біологічний процес | • розвиток ока • blood vessel development • animal organ morphogenesis • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • transcription, DNA-templated • central nervous system development • response to wounding • диференціація клітин • cornea development in camera-type eye • negative regulation of neurogenesis • зір • iris morphogenesis • multicellular organism development • neuron fate commitment • Убіквітин-залежний протеоліз • GO:1901227 negative regulation of transcription by RNA polymerase II • establishment of mitotic spindle orientation • Детермінація • neuron migration • GO:0033128 negative regulation of protein phosphorylation • positive regulation of neuroblast proliferation • lens development in camera-type eye • регіоналізація • type B pancreatic cell differentiation • pancreatic A cell development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • smoothened signaling pathway • аксоноґенеза • axon guidance • brain development • salivary gland morphogenesis • negative regulation of cell population proliferation • regulation of asymmetric cell division • dorsal/ventral axis specification • anterior/posterior pattern specification • dorsal/ventral pattern formation • регуляція експресії генів • GO:1901313 positive regulation of gene expression • pallium development • oligodendrocyte cell fate specification • cerebral cortex regionalization • forebrain dorsal/ventral pattern formation • commitment of neuronal cell to specific neuron type in forebrain • forebrain-midbrain boundary formation • telencephalon regionalization • pituitary gland development • habenula development • signal transduction involved in regulation of gene expression • keratinocyte differentiation • regulation of cell migration • positive regulation of epithelial cell differentiation • forebrain development • lacrimal gland development • protein localization to organelle • eye photoreceptor cell development • camera-type eye development • cell fate commitment • negative regulation of neuron differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of timing of cell differentiation • embryonic camera-type eye morphogenesis • astrocyte differentiation • negative regulation of epithelial cell proliferation • regulation of neurogenesis • retina development in camera-type eye • cellular response to leukemia inhibitory factor • negative regulation of neural precursor cell proliferation • positive regulation of core promoter binding |
---|
Джерела:Amigo / QuickGO | |
Шаблон експресії |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/8/80/PBB_GE_PAX6_205646_s_at_fs.png/250px-PBB_GE_PAX6_205646_s_at_fs.png) |
Більше даних |
Ортологи |
---|
Види | Людина | Миша |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (мРНК) | NM_000280 NM_001127612 NM_001258462 NM_001258463 NM_001258464
| NM_001258465 NM_001310158 NM_001310159 NM_001310160 NM_001310161 NM_001604 |
| NM_001244198 NM_001244200 NM_001244201 NM_001244202 NM_013627
| NM_001310144 NM_001310145 NM_001310146 |
|
---|
RefSeq (білок) | NP_000271 NP_001121084 NP_001245391 NP_001245392 NP_001245393
| NP_001245394 NP_001297087 NP_001297088 NP_001297089 NP_001297090 NP_001595 NP_001355816 NP_001355817 NP_001355818 NP_001355819 NP_001355820 NP_001355821 NP_001355822 NP_001355823 NP_001355828 NP_001355829 NP_001355830 NP_001355831 NP_001355832 NP_001355833 NP_001355834 NP_001355835 NP_001355836 NP_001355837 NP_001355838 NP_001355839 NP_001355840 NP_001355841 NP_001355842 NP_001355843 NP_001355844 NP_001355845 NP_001355846 NP_001355847 NP_001355848 NP_001355849 NP_001355850 NP_001355851 NP_001355852 NP_001355853 NP_001355854 NP_001355855 NP_001355856 NP_001355857 NP_001355858 NP_001355859 |
| NP_001231127 NP_001231129 NP_001231130 NP_001231131 NP_001297073
| NP_001297074 NP_001297075 NP_038655 |
|
---|
Локус (UCSC) | Хр. 11: 31.78 – 31.82 Mb | Хр. 2: 105.5 – 105.53 Mb |
---|
PubMed search | [2] | [3] |
---|
Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
|