| PTGS2 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR | | |
| Ідентифікатори |
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| Символи | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2 |
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| Зовнішні ІД | OMIM: 600262 MGI: 97798 HomoloGene: 31000 GeneCards: PTGS2 |
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| шифр КФ | 1.14.99.1 |
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| Реагує на сполуку |
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| ацетилсаліцилова кислота, benzquinamide, carprofen, целекоксиб, диклофенак, етодолак, Еторикоксиб, флурбіпрофен, ібупрофен, кетопрофен, кеторолак, lumiracoxib, meclofenamic acid, мефенамінова кислота, мелоксикам, напроксен, німесулід, NS-398, oxaprozin, парацетамол, фенілбутазон, піроксикам, Резвератрол, рофекоксиб, suprofen, valdecoxib, напроксен, diclofenac sodium, iguratimod, oxaprozin, apricoxib, ацетилсаліцилова кислота, ібупрофен, polmacoxib, кеторолак, isoxicam, диклофенак, етодолак, bromfenac, (RS)-fenoprofen, діфлунізал, esflurbiprofen, diclofenac potassium, (RS)-fenoprofen calcium dihydrate, ketorolac tromethamine, naproxen sodium, tolmetin sodium[1] |
| Онтологія гена |
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| Молекулярна функція | • arachidonate 15-lipoxygenase activity
• зв'язування з іоном металу
• heme binding
• enzyme binding
• oxidoreductase activity
• protein homodimerization activity
• dioxygenase activity
• GO:0001948, GO:0016582 protein binding
• peroxidase activity
• prostaglandin-endoperoxide synthase activity
• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• transferase activity
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| Клітинна компонента | • цитоплазма
• endoplasmic reticulum lumen
• мембрана
• caveola
• neuron projection
• organelle membrane
• ендоплазматичний ретикулум
• внутрішньоклітинна мембранна органела
• endoplasmic reticulum membrane
• GO:0009327 protein-containing complex
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| Біологічний процес | • response to fructose
• навчення
• response to organic substance
• lipoxygenase pathway
• cellular response to mechanical stimulus
• response to manganese ion
• Ангіогенез
• cellular response to hypoxia
• embryo implantation
• negative regulation of cell population proliferation
• response to cytokine
• negative regulation of smooth muscle contraction
• пам'ять
• GO:0001306 response to oxidative stress
• maintenance of blood-brain barrier
• response to lithium ion
• response to tumor necrosis factor
• fatty acid biosynthetic process
• positive regulation of synaptic transmission, glutamatergic
• positive regulation of vasoconstriction
• response to organonitrogen compound
• inflammatory response
• positive regulation of smooth muscle contraction
• bone mineralization
• response to fatty acid
• response to vitamin D
• cellular response to UV
• positive regulation of fever generation
• cellular response to fluid shear stress
• positive regulation of synaptic plasticity
• regulation of blood pressure
• response to lipopolysaccharide
• positive regulation of platelet-derived growth factor production
• regulation of inflammatory response
• brown fat cell differentiation
• sensory perception of pain
• response to radiation
• prostaglandin biosynthetic process
• cellular response to ATP
• овуляція
• positive regulation of smooth muscle cell proliferation
• hair cycle
• response to estradiol
• positive regulation of cell death
• positive regulation of cell migration involved in sprouting angiogenesis
• GO:1904578 response to organic cyclic compound
• lipid metabolism
• positive regulation of nitric oxide biosynthetic process
• response to glucocorticoid
• cyclooxygenase pathway
• fatty acid metabolic process
• positive regulation of fibroblast growth factor production
• decidualization
• regulation of cell population proliferation
• positive regulation of cell population proliferation
• negative regulation of calcium ion transport
• positive regulation of apoptotic process
• positive regulation of transforming growth factor beta production
• positive regulation of vascular endothelial growth factor production
• positive regulation of brown fat cell differentiation
• negative regulation of synaptic transmission, dopaminergic
• cellular oxidant detoxification
• GO:0010260 старіння людини
• NAD biosynthesis via nicotinamide riboside salvage pathway
• cellular response to heat
• positive regulation of prostaglandin biosynthetic process
• positive regulation of peptidyl-serine phosphorylation
• negative regulation of apoptotic process
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
• cellular response to non-ionic osmotic stress
• negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
• cellular response to lead ion
• response to angiotensin
• prostaglandin metabolic process
• positive regulation of protein import into nucleus
• cytokine-mediated signaling pathway
• long-chain fatty acid biosynthetic process
• negative regulation of cell cycle
• regulation of neuroinflammatory response
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | |
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| RefSeq (білок) | | |
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| Локус (UCSC) | Хр. 1: 186.67 – 186.68 Mb | Хр. 1: 149.98 – 149.98 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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