TCF4 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | | |
Ідентифікатори |
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Символи | TCF4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19, FECD3, transcription factor 4, CDG2T |
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Зовнішні ІД | OMIM: 602272 MGI: 98506 HomoloGene: 2407 GeneCards: TCF4 |
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Пов'язані генетичні захворювання |
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morbid obesity, шизофренія, неспецифічний виразковий коліт, sclerosing cholangitis, Fuchs' endothelial dystrophy, Pitt-Hopkins syndrome, Fuchs' endothelial dystrophy[1] |
Онтологія гена |
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Молекулярна функція | • protein dimerization activity • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • bHLH transcription factor binding • E-box binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding • TFIIB-class transcription factor binding • protein heterodimerization activity • DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
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Клітинна компонента | • transcription regulator complex • клітинне ядро • beta-catenin-TCF complex • beta-catenin-TCF7L2 complex |
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Біологічний процес | • диференціація клітин • GO:0009373 regulation of transcription, DNA-templated • protein-DNA complex assembly • transcription, DNA-templated • нейробіологія розвитку • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • DNA-templated transcription, initiation • transcription initiation from RNA polymerase II promoter • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of neuron differentiation |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001083962 NM_001243226 NM_001243227 NM_001243228 NM_001243230
| NM_001243231 NM_001243232 NM_001243233 NM_001243234 NM_001243235 NM_001243236 NM_001306207 NM_001306208 NM_003199 NM_001330604 NM_001330605 NM_001348211 NM_001348212 NM_001348213 NM_001348214 NM_001348215 NM_001348216 NM_001348217 NM_001348218 NM_001348219 NM_001348220 NM_001369572 NM_001369573 NM_001369574 NM_001369575 NM_001369576 NM_001369577 NM_001369578 NM_001369579 NM_001369580 NM_001369581 NM_001369582 NM_001369583 NM_001369584 NM_001369585 NM_001369586 NM_001369567 NM_001369568 NM_001369569 NM_001369570 NM_001369571 |
| NM_001083967 NM_013685 NM_001361126 NM_001361127 NM_001361128
| NM_001361129 |
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RefSeq (білок) | NP_001077431 NP_001230155 NP_001230156 NP_001230157 NP_001230159
| NP_001230160 NP_001230161 NP_001230162 NP_001230163 NP_001230164 NP_001230165 NP_001293136 NP_001293137 NP_001317533 NP_001317534 NP_003190 NP_001335140 NP_001335141 NP_001335142 NP_001335143 NP_001335144 NP_001335145 NP_001335146 NP_001335147 NP_001335148 NP_001335149 NP_001356501 NP_001356502 NP_001356503 NP_001356504 NP_001356505 NP_001356506 NP_001356507 NP_001356508 NP_001356509 NP_001356510 NP_001356511 NP_001356512 NP_001356513 NP_001356514 NP_001356515 NP_001356496 NP_001356497 NP_001356498 NP_001356499 NP_001356500 |
| NP_001077436 NP_038713 NP_001348055 NP_001348056 NP_001348057
| NP_001348058 |
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Локус (UCSC) | Хр. 18: 55.22 – 55.66 Mb | Хр. 18: 69.34 – 69.69 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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