TREX1 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2IOC, 2O4G, 2O4I, 2OA8, 3B6O, 3B6P, 3MXI, 3MXJ, 3MXM, 3U3Y, 3U6F, 4YNQ | | |
Ідентифікатори |
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Символи | TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1, RVCLS |
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Зовнішні ІД | OMIM: 606609 MGI: 1328317 HomoloGene: 7982 GeneCards: TREX1 |
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Пов'язані генетичні захворювання |
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ожиріння, Aicardi-Goutieres syndrome, autosomal dominant retinal vasculopathy with cerebral leukodystrophy, HERNS syndrome[1] |
Онтологія гена |
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Молекулярна функція | • protein homodimerization activity • зв'язування з іоном металу • single-stranded DNA binding • exodeoxyribonuclease III activity • MutSalpha complex binding • GO:0001948, GO:0016582 protein binding • 3'-5'-exodeoxyribonuclease activity • MutLalpha complex binding • nucleic acid binding • nuclease activity • exonuclease activity • hydrolase activity • 3'-5' exonuclease activity • double-stranded DNA binding • adenyl deoxyribonucleotide binding • magnesium ion binding • DNA binding • DNA binding, bending • WW domain binding |
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Клітинна компонента | • цитоплазма • nuclear envelope • endoplasmic reticulum membrane • мембрана • ендоплазматичний ретикулум • клітинне ядро • гіалоплазма • oligosaccharyltransferase complex • protein-DNA complex • nuclear replication fork |
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Біологічний процес | • DNA recombination • regulation of type I interferon production • реплікація ДНК • DNA mismatch repair • nucleic acid phosphodiester bond hydrolysis • DNA metabolic process • GO:0100026 Репарація ДНК • cellular response to interferon-beta • blood vessel development • розвиток нирки • адаптивна імунна відповідь • organ or tissue specific immune response • activation of immune response • macrophage activation involved in immune response • lymphoid progenitor cell differentiation • immune response in brain or nervous system • inflammatory response to antigenic stimulus • T cell antigen processing and presentation • regulation of immunoglobulin production • heart morphogenesis • heart process • atrial cardiac muscle tissue development • generation of precursor metabolites and energy • regulation of glycolytic process • DNA modification • DNA catabolic process • inflammatory response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • cellular response to DNA damage stimulus • determination of adult lifespan • response to UV • регуляція експресії генів • regulation of fatty acid metabolic process • regulation of cellular metabolic process • transposition, RNA-mediated • DNA duplex unwinding • interferon-alpha production • regulation of tumor necrosis factor production • cellular response to oxidative stress • GO:0072353 cellular response to reactive oxygen species • cellular response to UV • CD86 biosynthetic process • apoptotic cell clearance • regulation of cellular respiration • вроджений імунітет • regulation of innate immune response • establishment of protein localization • regulation of lipid biosynthetic process • regulation of inflammatory response • GO:0048552 regulation of catalytic activity • protein stabilization • regulation of T cell activation • defense response to virus • type I interferon signaling pathway • negative regulation of type I interferon-mediated signaling pathway • regulation of protein complex stability • cellular response to organic substance • cellular response to type I interferon • cellular response to gamma radiation • cellular response to hydroxyurea • immune complex formation • DNA synthesis involved in UV-damage excision repair • regulation of lysosome organization |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_033629 NM_007248 NM_016381 NM_033627 NM_033628 |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 3: 48.47 – 48.47 Mb | Хр. 9: 108.89 – 108.89 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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