胱天蛋白酶14 |
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識別號 |
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别名 | CASP14;, caspase 14, ARCI12 |
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外部ID | OMIM:605848 MGI:1335092 HomoloGene:36304 GeneCards:CASP14 |
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為以下藥物的標靶 |
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emricasan[1] |
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基因位置(小鼠) |
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![小鼠10号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | 染色体 | 小鼠10号染色体[3] |
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| 基因座 | 10|10 C1 | 起始 | 78,547,825 bp[3] |
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终止 | 78,554,128 bp[3] |
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基因本體 |
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分子功能 | • 肽酶活性 • cysteine-type endopeptidase activity • 半胱氨酸型肽酶活性 • 血浆蛋白结合 • 水解酶活性 • endopeptidase activity • cysteine-type endopeptidase activity involved in execution phase of apoptosis • cysteine-type endopeptidase activity involved in apoptotic process
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細胞組分 | • 細胞質 • keratin filament • 细胞核 • 细胞质基质 • 線粒體
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生物學過程 | • cornification • 细胞分化 • keratinization • 蛋白酶解 • epidermis development • execution phase of apoptosis • 细胞凋亡 • intrinsic apoptotic signaling pathway in response to DNA damage
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 19: 15.05 – 15.06 Mb | Chr 10: 78.55 – 78.55 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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胱天蛋白酶14(英语:Caspase 14)是一种在人类中由CASP14基因编码的酶。[6][7][8]
胱天蛋白酶14属于胱天蛋白酶家族的成员。胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。胱天蛋白酶以无活性的酶原形式存在,在保守的天冬氨酸残基处经历蛋白水解加工,产生一大一小两个亚基,然后二聚化形成活性酶。该酶已被证明在体外被胱天蛋白酶8和10加工和激活,而在体内则被抗Fas激动剂抗体或TNF相关凋亡诱导配体加工和激活。这种胱天蛋白酶的表达和加工可能参与角质形成细胞终末分化,这对于皮肤屏障的形成很重要。[8]
根据人类蛋白质图谱(英语:Human Protein Atlas)[9],CASP14蛋白在人类皮肤中富集,主要表达于表皮上层。根据细胞图谱,该蛋白质主要定位于细胞质。[10]
参见
- 蛋白酶解图谱(英语:The Proteolysis Map)
- 胱天蛋白酶
参考文献
- ^ 對Caspase 14起作用的藥物;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000105141 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000005355 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P. Identification of a new caspase homologue: caspase-14. Cell Death Differ. May 1999, 5 (10): 838–46. PMID 10203698. doi:10.1038/sj.cdd.4400444
. - ^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. Dec 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648
. - ^ 8.0 8.1 Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase.
- ^ Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina. Tissue-based map of the human proteome. Science. 2015-01-23, 347 (6220): 1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377. doi:10.1126/science.1260419 (英语).
- ^ Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars. A subcellular map of the human proteome. Science. 2017-05-26, 356 (6340): eaal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558. doi:10.1126/science.aal3321 (英语).
拓展阅读
- Rasmussen HH, van Damme J, Puype M, et al. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.. Electrophoresis. 1993, 13 (12): 960–9. PMID 1286667. S2CID 41855774. doi:10.1002/elps.11501301199.
- Ahmad M, Srinivasula SM, Hegde R, et al. Identification and characterization of murine caspase-14, a new member of the caspase family.. Cancer Res. 1998, 58 (22): 5201–5. PMID 9823333.
- Eckhart L, Ban J, Fischer H, Tschachler E. Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation.. Biochem. Biophys. Res. Commun. 2000, 277 (3): 655–9. PMID 11062009. doi:10.1006/bbrc.2000.3698.
- Eckhart L, Declercq W, Ban J, et al. Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.. J. Invest. Dermatol. 2001, 115 (6): 1148–51. PMID 11121154. doi:10.1046/j.1523-1747.2000.00205.x
. - Lippens S, Kockx M, Knaapen M, et al. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.. Cell Death Differ. 2001, 7 (12): 1218–24. PMID 11175259. doi:10.1038/sj.cdd.4400785
. - Pistritto G, Jost M, Srinivasula SM, et al. Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.. Cell Death Differ. 2003, 9 (9): 995–1006. PMID 12181750. S2CID 23933663. doi:10.1038/sj.cdd.4401061.
- Chien AJ, Presland RB, Kuechle MK. Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.. Biochem. Biophys. Res. Commun. 2002, 296 (4): 911–7. PMID 12200134. doi:10.1016/S0006-291X(02)02015-6.
- Rendl M, Ban J, Mrass P, et al. Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner.. J. Invest. Dermatol. 2003, 119 (5): 1150–5. PMID 12445205. doi:10.1046/j.1523-1747.2002.19532.x
. - Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899
. - Lippens S, Kockx M, Denecker G, et al. Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.. Am. J. Pathol. 2004, 165 (3): 833–41. PMC 1618612
. PMID 15331408. doi:10.1016/s0002-9440(10)63346-9. - Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504. - Walsh DS, Borke JL, Singh BB, et al. Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation.. J. Dermatol. Sci. 2005, 37 (1): 61–3 [2024-02-25]. PMID 15619438. doi:10.1016/j.jdermsci.2004.10.003. (原始内容存档于2023-03-30).
- Koenig U, Sommergruber W, Lippens S. Aberrant expression of caspase-14 in epithelial tumors.. Biochem. Biophys. Res. Commun. 2005, 335 (2): 309–13. PMID 16061209. doi:10.1016/j.bbrc.2005.07.072.
- Krajewska M, Kim H, Shin E, et al. Tumor-associated alterations in caspase-14 expression in epithelial malignancies.. Clin. Cancer Res. 2006, 11 (15): 5462–71. PMID 16061862. doi:10.1158/1078-0432.CCR-04-2527
. - Kam DW, Charles AK, Dharmarajan AM. Caspase-14 expression in the human placenta.. Reprod. Biomed. Online. 2005, 11 (2): 236–43. PMID 16168224. doi:10.1016/S1472-6483(10)60964-9
. - Park K, Kuechle MK, Choe Y, et al. Expression and characterization of constitutively active human caspase-14.. Biochem. Biophys. Res. Commun. 2006, 347 (4): 941–8. PMID 16854378. doi:10.1016/j.bbrc.2006.06.156.
- White L, Dharmarajan A, Charles A. Caspase-14: a new player in cytotrophoblast differentiation.. Reprod. Biomed. Online. 2007, 14 (3): 300–7. PMID 17359582. doi:10.1016/S1472-6483(10)60871-1
. - Hsu S, Qin H, Dickinson D, et al. Expression of caspase-14 reduces tumorigenicity of skin cancer cells.. In Vivo. 2007, 21 (2): 279–83. PMID 17436577.
外部链接
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| 胱天蛋白酶 | |
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| 来自果实 | |
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| 钙蛋白酶 | - CAPN1
- CAPN2
- CAPN3
- CAPN5
- CAPN6
- CAPN7
- CAPN8
- CAPN9
- CAPN10
- CAPN11
- CAPN12
- CAPN13
- CAPN14
- CAPNS1
- CAPNS2
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| 组织蛋白酶 | |
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| 其它 | - 梭菌蛋白酶
- 癌性促凝物质
- 分离酶(英语:Separase)
- Autophagin
- Cruzipain
- 3C样蛋白酶
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| EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3(英语:Template:Ligases CO CS and CN)/4/5-6 |
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| 活性 | |
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| 调节 | |
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| 分类 | |
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| 动力学 | - 酶动力学
- 伊迪-霍夫斯蒂图(英语:Eadie–Hofstee diagram)
- 哈尼斯-伍尔夫图(英语:Hanes–Woolf plot)
- 双倒数图
- 米氏动力学
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| 类型 | - EC1 氧化還原酶(列表(英语:List of EC numbers (EC 1)))
- EC2 轉移酶(列表(英语:List of EC numbers (EC 2)))
- EC3 水解酶(列表(英语:List of EC numbers (EC 3)))
- EC4 裂合酶(列表(英语:List of EC numbers (EC 4)))
- EC5 異構酶(列表(英语:List of EC numbers (EC 5)))
- EC6 連接酶(列表(英语:List of EC numbers (EC 6)))
- EC7 移位酶(英语:Translocase)(列表(英语:List of EC numbers (EC 7)))
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