MUC7

MUC7是智人的蛋白质編碼基因的一部分，位於4號人類染色體的短臂[1]，負責編碼Mucin-7這一種蛋白質[2][3]。該蛋白的多肽鏈長度為377個氨基酸，分子量為39,159[4]。在其他動物，MUC7基因只見於大多數的胎盤動物；但在有袋類物種的基因卻找不到[5]。

人類變異

人類的基因攜帶有五個或六個串联重复版本；而在其他靈長類動物中，這個基因的重複次數，在大猩猩為4-5次，在黑猩猩為5次，猩猩屬物種則為6-7次，獼猴為8-10次，狒狒屬為10-11次，绿猴為11-12次[5]。根據一項2017年由美國紐約州立大學水牛城分校研究人員及其他機構合作，透過分析人類唾液中MUC7黏蛋白的演化過程，生物學家發現在大約15萬年前，撒哈拉以南非洲的人類祖先曾與一種前所未知的原始人類有過基因交流；而這人種並不屬於今人的人類、以及尼安德特人與丹尼索瓦人，可能是直立人的一支，被生物學家冠以“幽靈人種”（ghost species）的名稱[6][7]。

參考文獻

  1. ^ HUGO Gene Nomenclature Commitee, HGNC:7518. [2017-08-30]. （原始内容存档于2015-09-10） （英语）. 
  2. ^ Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ. Structure and chromosomal localization of the human salivary mucin gene, MUC7. Genomics. February 1996, 31 (3): 277–82. PMID 8838308. doi:10.1006/geno.1996.0049. 
  3. ^ Entrez Gene: MUC7 mucin 7, secreted. 
  4. ^ UniProt, Q8TAX7. [2017-08-30]. （原始内容存档于2016-09-22） （英语）. 
  5. ^ 5.0 5.1 Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O. Recent evolution of the salivary mucin MUC7. Scientific Reports. August 2016, 6: 31791. Bibcode:2016NatSR...631791X. PMC 4997351 可免费查阅. PMID 27558399. doi:10.1038/srep31791.  This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) （页面存档备份，存于互联网档案馆） license.
  6. ^ 研究：部份人類祖先曾跟「幽靈人種」雜交 交流是常態. ETtoday新聞雲. 2017-07-25 [2023-08-15]. （原始内容存档于2023-08-15） （中文（繁體））. 
  7. ^ 部分现代人祖先曾与未知“幽灵”人种杂交. 新华社. 2017-07-25 [2023-08-15]. （原始内容存档于2021-10-10） （中文（简体））. 

延伸閱讀

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外部連結