CCP110

Protein-coding gene in the species Homo sapiens
CCP110
Identifiers
AliasesCCP110, CP110, Cep110, centriolar coiled-coil protein 110kDa, centriolar coiled-coil protein 110
External IDsOMIM: 609544; MGI: 2141942; HomoloGene: 8810; GeneCards: CCP110; OMA:CCP110 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CCP110
Genomic location for CCP110
Band16p12.3Start19,523,811 bp[1]
End19,553,408 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CCP110
Genomic location for CCP110
Band7|7 F2Start118,311,775 bp[2]
End118,336,247 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • optic nerve

  • corpus callosum

  • globus pallidus

  • internal globus pallidus

  • external globus pallidus

  • buccal mucosa cell

  • bronchial epithelial cell

  • inferior ganglion of vagus nerve

  • pars reticulata

  • subthalamic nucleus
Top expressed in
  • superior cervical ganglion

  • olfactory epithelium

  • zygote

  • hand

  • spermatocyte

  • seminiferous tubule

  • secondary oocyte

  • lateral geniculate nucleus

  • globus pallidus

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cell projection
  • cytosol
  • centriole
  • cytoplasm
  • centrosome
  • cilium
  • microtubule organizing center
  • cytoskeleton
  • protein-containing complex
Biological process
  • cell projection organization
  • G2/M transition of mitotic cell cycle
  • negative regulation of cilium assembly
  • centriole replication
  • positive regulation of cilium assembly
  • ciliary basal body organization
  • centrosome duplication
  • regulation of cytokinesis
  • protein deubiquitination
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9738

101565

Ensembl

ENSG00000103540

ENSMUSG00000033904

UniProt

O43303

Q7TSH4

RefSeq (mRNA)
NM_001199022
NM_014711
NM_001323569
NM_001323570
NM_001323571

NM_001323572
NM_001323576
NM_001323577

NM_182995
NM_001360793
NM_001360794

RefSeq (protein)
NP_001185951
NP_001310498
NP_001310499
NP_001310500
NP_001310501

NP_001310505
NP_001310506
NP_055526

NP_892040
NP_001347722
NP_001347723

Location (UCSC)Chr 16: 19.52 – 19.55 MbChr 7: 118.31 – 118.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication.[5][6] CP110 suppresses a cilia assembly program.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103540 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033904 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD (September 2002). "CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells". Dev. Cell. 3 (3): 339–50. doi:10.1016/S1534-5807(02)00258-7. PMID 12361598.
  6. ^ Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD (March 2013). "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110". Nature. 495 (7440): 255–9. Bibcode:2013Natur.495..255L. doi:10.1038/nature11941. PMC 3815529. PMID 23486064.
  7. ^ Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell. 130 (4): 678–90. doi:10.1016/j.cell.2007.06.027. PMID 17719545. S2CID 17974875.

Further reading

  • Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zou C, Li J, Bai Y, et al. (2006). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". J. Cell Biol. 171 (3): 437–45. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.
  • Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability". Mol. Biol. Cell. 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247. PMID 16760425.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Pearson CG, Culver BP, Winey M (2007). "Centrioles want to move out and make cilia". Dev. Cell. 13 (3): 319–21. doi:10.1016/j.devcel.2007.08.007. PMID 17765674.


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