CNTROB

Protein-coding gene in the species Homo sapiens
CNTROB
Identifiers
AliasesCNTROB, LIP8, PP1221, centrobin, centriole duplication and spindle assembly protein
External IDsOMIM: 611425; MGI: 2443290; HomoloGene: 14205; GeneCards: CNTROB; OMA:CNTROB - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CNTROB
Genomic location for CNTROB
Band17p13.1Start7,932,101 bp[1]
End7,949,920 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CNTROB
Genomic location for CNTROB
Band11|11 B3Start69,299,487 bp[2]
End69,323,775 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • ventricular zone

  • body of uterus

  • ganglionic eminence

  • right lung

  • upper lobe of left lung

  • pancreatic ductal cell

  • canal of the cervix

  • cardiac muscle tissue of right atrium
Top expressed in
  • superior surface of tongue

  • gallbladder

  • ventricular zone

  • otic vesicle

  • neural layer of retina

  • secondary oocyte

  • spermatocyte

  • zygote

  • thymus

  • primary oocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • protein domain specific binding
Cellular component
  • centriole
  • centrosome
  • cytoskeleton
  • cytoplasm
  • cytosol
Biological process
  • cell cycle
  • mitotic cytokinetic process
  • centrosome separation
  • cell division
  • centriole replication
  • regulation of cilium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116840

216846

Ensembl

ENSG00000170037

ENSMUSG00000032782

UniProt

Q8N137

Q8CB62

RefSeq (mRNA)
NM_001037144
NM_053051
NM_001330124
NM_001353202
NM_001353203

NM_001353204
NM_001353205
NM_001353206
NM_001353207
NM_001353208
NM_001353209

NM_172560

RefSeq (protein)
NP_001032221
NP_001317053
NP_444279
NP_001340131
NP_001340132

NP_001340133
NP_001340134
NP_001340135
NP_001340136
NP_001340137
NP_001340138

NP_766148

Location (UCSC)Chr 17: 7.93 – 7.95 MbChr 11: 69.3 – 69.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrobin is a protein that in humans is encoded by the CNTROB gene.[5] It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.[6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170037 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032782 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
  6. ^ Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology. 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.

Further reading

  • Jeong Y, Lee J, Kim K, et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization". J. Cell Sci. 120 (Pt 12): 2106–16. doi:10.1242/jcs.03458. PMID 17535851.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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