CD3EAP

Protein-coding gene in the species Homo sapiens
POLR1G
Identifiers
AliasesPOLR1G, ASE-1, ASE1, CAST, PAF49, CD3e molecule associated protein, RPA34, RNA polymerase I subunit G, CD3EAP
External IDsOMIM: 107325; MGI: 1917583; HomoloGene: 17107; GeneCards: POLR1G; OMA:POLR1G - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for POLR1G
Genomic location for POLR1G
Band19q13.32Start45,406,644 bp[1]
End45,410,737 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for POLR1G
Genomic location for POLR1G
Band7|7 A3Start19,089,939 bp[2]
End19,093,408 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • oocyte

  • secondary oocyte

  • testicle

  • mucosa of urinary bladder

  • tibialis anterior muscle

  • buccal mucosa cell

  • gingival epithelium

  • gastrocnemius muscle

  • endothelial cell
Top expressed in
  • otic vesicle

  • hand

  • internal carotid artery

  • fossa

  • external carotid artery

  • epiblast

  • Paneth cell

  • condyle

  • muscle of thigh

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-directed 5'-3' RNA polymerase activity
  • RNA binding
Cellular component
  • RNA polymerase I complex
  • RNA polymerase I transcription regulator complex
  • mitochondrion
  • nucleus
  • nucleoplasm
  • chromosome
  • fibrillar center
  • nucleolus
  • cytosol
Biological process
  • transcription initiation from RNA polymerase I promoter
  • termination of RNA polymerase I transcription
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • rRNA transcription
  • transcription elongation from RNA polymerase I promoter
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • transcription by RNA polymerase I
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10849

70333

Ensembl

ENSG00000117877

ENSMUSG00000047649

UniProt

O15446

Q76KJ5

RefSeq (mRNA)

NM_012099
NM_001297590

NM_145822

RefSeq (protein)

NP_001284519
NP_036231

NP_665821

Location (UCSC)Chr 19: 45.41 – 45.41 MbChr 7: 19.09 – 19.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene.[5][6][7][8]

Interactions

CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain,[5] POLR1E[7] and POLR1C.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117877 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047649 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (Jul 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J Biol Chem. 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. PMID 10373416.
  6. ^ Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (Mar 1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes". Chromosoma. 106 (8): 493–502. doi:10.1007/s004120050271. PMID 9426281. S2CID 10684078.
  7. ^ a b c Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jun 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol Cell Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
  8. ^ "Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
  • Panov KI, Panova TB, Gadal O, et al. (2006). "RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor". Mol. Cell. Biol. 26 (14): 5436–48. doi:10.1128/MCB.00230-06. PMC 1592716. PMID 16809778.
  • Skjelbred CF, Saebø M, Nexø BA, et al. (2006). "Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study". BMC Cancer. 6: 175. doi:10.1186/1471-2407-6-175. PMC 1533843. PMID 16817948.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.


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