POLR1E

Protein-coding gene in the species Homo sapiens

POLR1E

Identifiers

Aliases

POLR1E, PAF53, PRAF1, polymerase (RNA) I subunit E, RNA polymerase I subunit E, A49, RPA49

External IDs

MGI: 1929022; HomoloGene: 41486; GeneCards: POLR1E; OMA:POLR1E - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p13.2	Start	37,485,948 bp^[1]
Band	9p13.2	End	37,503,697 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 B1	Start	45,018,583 bp^[2]
Band	4\|4 B1	End	45,036,565 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

body of pancreas

left ovary

Achilles tendon

gonad

body of uterus

right ovary

secondary oocyte

ganglionic eminence

ectocervix

left uterine tube

Top expressed in

otic placode

saccule

embryo

otic vesicle

spermatocyte

morula

epiblast

embryo

tail of embryo

primitive streak

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity DNA binding RNA polymerase I general transcription initiation factor binding RNA polymerase I activity
Cellular component	nucleus nucleoplasm fibrillar center nucleolus RNA polymerase I complex
Biological process	transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation transcription, DNA-templated RNA polymerase I preinitiation complex assembly transcription elongation from RNA polymerase I promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64425


64424

Ensembl


ENSG00000137054


ENSMUSG00000028318

UniProt


Q9GZS1


Q8K202

RefSeq (mRNA)


NM_001282766 NM_022490


NM_001285800 NM_022811

RefSeq (protein)


NP_001269695 NP_071935


NP_001272729 NP_073722

Location (UCSC)

Chr 9: 37.49 – 37.5 Mb

Chr 4: 45.02 – 45.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase I subunit RPA49 is an enzyme that in humans is encoded by the POLR1E gene.^[5]^[6]

Interactions

POLR1E has been shown to interact with CD3EAP^[7] and POLR1C.^[8]^[7]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137054 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028318 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanada K, Song CZ, Yamamoto K, Yano K, Maeda Y, Yamaguchi K, Muramatsu M (May 1996). "RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription". The EMBO Journal. 15 (9): 2217–26. doi:10.1002/j.1460-2075.1996.tb00575.x. PMC 450146. PMID 8641287.
^ "Entrez Gene: POLR1E polymerase (RNA) I polypeptide E, 53kDa".
^ ^a ^b Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Seither P, Zatsepina O, Hoffmann M, Grummt I (Sep 1997). "Constitutive and strong association of PAF53 with RNA polymerase I". Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID 9254723. S2CID 23487728.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Seither P, Zatsepina O, Hoffmann M, Grummt I (Sep 1997). "Constitutive and strong association of PAF53 with RNA polymerase I". Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID 9254723. S2CID 23487728.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Voit R, Grummt I (Nov 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 13631–6. Bibcode:2001PNAS...9813631V. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Bjerregaard B, Wrenzycki C, Strejcek F, Laurincik J, Holm P, Ochs RL, Rosenkranz C, Callesen H, Rath D, Niemann H, Maddox-Hyttel P (Apr 2004). "Expression of nucleolar-related proteins in porcine preimplantation embryos produced in vivo and in vitro". Biology of Reproduction. 70 (4): 867–76. doi:10.1095/biolreprod.103.021683. PMID 14585813.
Baran V, Pavlok A, Bjerregaard B, Wrenzycki C, Hermann D, Philimonenko VV, Lapathitis G, Hozak P, Niemann H, Motlik J (Apr 2004). "Immunolocalization of upstream binding factor and pocket protein p130 during final stages of bovine oocyte growth". Biology of Reproduction. 70 (4): 877–86. doi:10.1095/biolreprod.103.018408. PMID 14613906. S2CID 43563796.
Bjerregaard B, Wrenzycki C, Philimonenko VV, Hozak P, Laurincik J, Niemann H, Motlik J, Maddox-Hyttel P (Apr 2004). "Regulation of ribosomal RNA synthesis during the final phases of porcine oocyte growth". Biology of Reproduction. 70 (4): 925–35. doi:10.1095/biolreprod.103.020941. PMID 14627545.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
Percipalle P, Fomproix N, Cavellán E, Voit R, Reimer G, Krüger T, Thyberg J, Scheer U, Grummt I, Farrants AK (May 2006). "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Reports. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC 1479564. PMID 16514417.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.