DNAJB2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | DNAJB2, DSMA5, HSJ-1, HSJ1, HSPF3, CMT2T, DnaJ heat shock protein family (Hsp40) member B2 |
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External IDs | OMIM: 604139; MGI: 1928739; HomoloGene: 4902; GeneCards: DNAJB2; OMA:DNAJB2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2q35 | Start | 219,279,342 bp[1] |
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End | 219,286,898 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 C4 | Start | 75,236,406 bp[2] |
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End | 75,245,692 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - C1 segment
- right hemisphere of cerebellum
- right frontal lobe
- anterior pituitary
- amygdala
- cingulate gyrus
- anterior cingulate cortex
- prefrontal cortex
- Brodmann area 9
- tibial nerve
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| Top expressed in | - motor neuron
- lens
- spermatid
- neural layer of retina
- supraoptic nucleus
- retinal pigment epithelium
- spermatocyte
- muscle of thigh
- aortic valve
- blood
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - polyubiquitin modification-dependent protein binding
- proteasome binding
- chaperone binding
- protein binding
- ubiquitin protein ligase binding
- ATPase activator activity
- Hsp70 protein binding
- unfolded protein binding
- ubiquitin binding
- ubiquitin-dependent protein binding
| Cellular component | - inclusion body
- proteasome complex
- cytosol
- nucleus
- cytoplasm
- endoplasmic reticulum
- endoplasmic reticulum membrane
- membrane
- intrinsic component of endoplasmic reticulum membrane
- nuclear membrane
| Biological process | - response to unfolded protein
- negative regulation of protein deubiquitination
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent ERAD pathway
- protein refolding
- negative regulation of inclusion body assembly
- regulation of protein localization
- regulation of protein ubiquitination
- negative regulation of protein binding
- positive regulation of ATP-dependent activity
- proteasome-mediated ubiquitin-dependent protein catabolic process
- chaperone-mediated protein folding
- regulation of chaperone-mediated protein folding
- negative regulation of cell population proliferation
- negative regulation of cell growth
- neuron cellular homeostasis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001159883 NM_001159884 NM_001159885 NM_020266 NM_178055 |
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RefSeq (protein) | | |
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NP_001153355 NP_001153356 NP_001153357 NP_064662 NP_835156 |
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Location (UCSC) | Chr 2: 219.28 – 219.29 Mb | Chr 1: 75.24 – 75.25 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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