HOMER2

Protein and coding gene in humans

HOMER2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1I7A

Identifiers

Aliases

HOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2

External IDs

OMIM: 604799; MGI: 1347354; HomoloGene: 3560; GeneCards: HOMER2; OMA:HOMER2 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q25.2	Start	82,836,946 bp^[1]
Band	15q25.2	End	82,986,153 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 D3	Start	81,250,229 bp^[2]
Band	7\|7 D3	End	81,357,275 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

body of pancreas

olfactory zone of nasal mucosa

muscle of thigh

minor salivary glands

gastrocnemius muscle

islet of Langerhans

Skeletal muscle tissue of rectus abdominis

skin of leg

parotid gland

skin of abdomen

Top expressed in

lacrimal gland

parotid gland

transitional epithelium of urinary bladder

lateral septal nucleus

substantia nigra

Region I of hippocampus proper

crypt of lieberkuhn of small intestine

epithelium of stomach

olfactory epithelium

trigeminal ganglion

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding protein homodimerization activity protein domain specific binding synaptic receptor adaptor activity actin binding G protein-coupled glutamate receptor binding glutamate receptor binding protein heterodimerization activity
Cellular component	cytoplasm neuronal cell body postsynaptic membrane dendrite synapse postsynaptic density membrane apical part of cell stereocilium tip cell projection stereocilium plasma membrane cell junction cytosol glutamatergic synapse neuron projection
Biological process	G protein-coupled glutamate receptor signaling pathway chemical homeostasis within a tissue behavioral response to cocaine regulation of G protein-coupled receptor signaling pathway hearing calcium-mediated signaling using intracellular calcium source negative regulation of interleukin-2 production negative regulation of calcineurin-NFAT signaling cascade regulation of store-operated calcium entry positive regulation of signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9455


26557

Ensembl


ENSG00000103942


ENSMUSG00000025813

UniProt


Q9NSB8


Q9QWW1

RefSeq (mRNA)


NM_004839 NM_199330 NM_199331 NM_199332


NM_001164086 NM_001164087 NM_011983 NM_177029

RefSeq (protein)


NP_004830 NP_955362


NP_001157558 NP_001157559 NP_036113

Location (UCSC)

Chr 15: 82.84 – 82.99 Mb

Chr 7: 81.25 – 81.36 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.^[5]^[6]^[7]

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.^[7]

Interactions

HOMER2 has been shown to interact with RYR1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103942 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025813 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
^ Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
^ ^a ^b "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
^ Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47). United States: 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.

Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". J. Mol. Biol. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
Feng W, Tu J, Yang T, et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
Kim JT, Park SH, Kim SK, et al. (2003). "Potential role of Homer-2a on cutaneous vascular anomaly". J. Korean Med. Sci. 17 (5): 636–40. doi:10.3346/jkms.2002.17.5.636. PMC 3054924. PMID 12378015.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T (2003). "Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons". Mol. Cell. Neurosci. 22 (2): 188–201. doi:10.1016/S1044-7431(03)00037-X. PMID 12676529. S2CID 38323844.
Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ishibashi T, Ogawa S, Hashiguchi Y, et al. (2005). "A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems". J. Biochem. 137 (5): 617–23. doi:10.1093/jb/mvi074. PMID 15944415.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Dahl JP, Kampman KM, Oslin DW, et al. (2006). "Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population". Psychiatr. Genet. 15 (4): 277–83. doi:10.1097/00041444-200512000-00010. PMID 16314758. S2CID 24128233.