HOMER3

Protein and coding gene in humans

HOMER3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2P8V, 3CVF

Identifiers
AliasesHOMER3, HOMER-3, VESL3, homer scaffolding protein 3, homer scaffold protein 3
External IDsOMIM: 604800; MGI: 1347359; HomoloGene: 37972; GeneCards: HOMER3; OMA:HOMER3 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for HOMER3
Genomic location for HOMER3
Band19p13.11Start18,929,201 bp[1]
End18,941,261 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for HOMER3
Genomic location for HOMER3
Band8|8 B3.3Start70,282,827 bp[2]
End70,294,361 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • right hemisphere of cerebellum

  • C1 segment

  • spleen

  • muscle of thigh

  • gastrocnemius muscle

  • inferior ganglion of vagus nerve

  • stromal cell of endometrium

  • ganglionic eminence

  • right lobe of thyroid gland
Top expressed in
  • cerebellar cortex

  • lobe of cerebellum

  • ventricular zone

  • yolk sac

  • cerebellar vermis

  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina

  • lip

  • ganglionic eminence

  • embryo
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein C-terminus binding
  • protein binding
  • protein domain specific binding
  • G protein-coupled glutamate receptor binding
  • identical protein binding
Cellular component
  • basal part of cell
  • cell junction
  • postsynaptic membrane
  • synapse
  • postsynaptic density
  • membrane
  • cytoplasm
  • cytosol
  • plasma membrane
  • cellular component
  • glutamatergic synapse
  • dendrite
  • neuron projection
Biological process
  • G protein-coupled glutamate receptor signaling pathway
  • protein targeting
  • negative regulation of interleukin-2 production
  • negative regulation of calcineurin-NFAT signaling cascade
  • regulation of postsynaptic neurotransmitter receptor activity
  • regulation of store-operated calcium entry
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9454

26558

Ensembl

ENSG00000051128

ENSMUSG00000003573

UniProt

Q9NSC5

Q99JP6

RefSeq (mRNA)

NM_001145721
NM_001145722
NM_001145724
NM_004838

NM_001146153
NM_011984

RefSeq (protein)
NP_001139193
NP_001139194
NP_001139196
NP_004829
NP_001139194.1

NP_001139196.1

NP_001139625
NP_036114

Location (UCSC)Chr 19: 18.93 – 18.94 MbChr 8: 70.28 – 70.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.[5][6][7]

Function

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.[7]

Interactions

HOMER3 has been shown to interact with TRPC1[8] and RYR1.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000051128 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003573 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Feb 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". Journal of Molecular Biology. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
  6. ^ Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554.
  7. ^ a b "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)".
  8. ^ Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576. S2CID 10552676.
  9. ^ Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.

Further reading

  • Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF (Mar 1997). "Homer: a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284–8. Bibcode:1997Natur.386..284B. doi:10.1038/386284a0. PMID 9069287. S2CID 4346579.
  • Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Oct 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458. S2CID 16431031.
  • Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
  • Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576. S2CID 10552676.
  • Ishiguro K, Xavier R (Mar 2004). "Homer-3 regulates activation of serum response element in T cells via its EVH1 domain". Blood. 103 (6): 2248–56. doi:10.1182/blood-2003-08-2671. PMID 14645007.
  • Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genetics. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
  • Schreiner D, Müller K, Hofer HW (Oct 2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins". FEBS Letters. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624. S2CID 10267922.
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