Phosphoribosylaminoimidazolesuccinocarboxamide
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Systematic IUPAC name (2S)-(5-Amino-1-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazole-4-carboxamido)butanedioic acid | |
Other names SAICAR; 2-[(5-Amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}imidazol-4-yl)formamido]butanedioic acid; N-{[5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl}-L-aspartic acid | |
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MeSH | SAICAR |
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Chemical formula | C13H19N4O12P |
Molar mass | 454.285 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) is an intermediate in the formation of purines. The conversion of ATP, L-aspartate, and 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide, ADP, and phosphate by phosphoribosylaminoimidazolesuccinocarboxamide synthetase (SAICAR synthetase) represents the eighth step of de novo purine nucleotide biosynthesis.[1]
References
- ^ Scott W. Nelson; Daniel J. Binkowski; Richard B. Honzatko; Herbert J. Fromm (2005). "Mechanism of Action of Escherichia coli Phosphoribosylaminoimidazolesuccinocarboxamide Synthetase". Biochemistry. 44 (2): 766–774. doi:10.1021/bi048191w. PMID 15641804. S2CID 41673787.
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