Edaravon
IUPAC ime | |
---|---|
5-metil-2-fenil-2,4-dihidro-3H-pirazol-3-on | |
Klinički podaci | |
Način primene | Oralno |
Pravni status | |
Pravni status |
|
Identifikatori | |
CAS broj | 89-25-8 Y |
ATC kod | none |
PubChem | CID 4021 |
ChemSpider | 3881 Y |
UNII | S798V6YJRP Y |
KEGG | D01552 Y |
ChEBI | CHEBI:31530 Y |
ChEMBL | CHEMBL290916 Y |
Sinonimi | MCI-186 |
Hemijski podaci | |
Formula | C10H10N2O |
Molarna masa | 174,20 g/mol |
SMILES
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InChI
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Edaravon (Radicut) je neuroprotektivni lek koji pomaže u neurološkom oporavku nakon akutne ishemije mozga i naknadne cerebralne infarkcije.[1] On deluje kao potentan antioksidans i jak sakupljaš slobodnih radikala, koji štiti od oksidativnog stresa i neuronalne apoptoze.[2][3][4] On je u prodaji u Japanu (od 2001)[1] i u Indiji.
Edaravon umanjuje dejstvo metamfetamina i 6-OHDA indukovanu dopaminergičku neurotoksičnost u strijatumu i substantia nigra, a nema efekta na metamfetaminom indukovano otpuštanje dopamina ili hipertermiju.[5][6] On takođe štiti protiv MPTP-posredovane dopaminergičke neurotoksičnosti u substantia nigra, mada ne i u strijatumu.[7][8][9]
Reference
- ^ а б Doherty, Annette M. (2002). Annual Reports in Medicinal Chemistry, Volume 37 (Annual Reports in Medicinal Chemistry). Boston: Academic Press. ISBN 978-0-12-040537-4.
- ^ Watanabe T, Tanaka M, Watanabe K, Takamatsu Y, Tobe A (2004). „[Research and development of the free radical scavenger edaravone as a neuroprotectant]”. Yakugaku Zasshi (на језику: Japanese). 124 (3): 99—111. PMID 15049127. CS1 одржавање: Непрепознат језик (веза)
- ^ Higashi Y, Jitsuiki D, Chayama K, Yoshizumi M (2006). „Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases”. Recent Patents on Cardiovascular Drug Discovery. 1 (1): 85—93. PMID 18221078.
- ^ Yoshida H, Yanai H, Namiki Y, Fukatsu-Sasaki K, Furutani N, Tada N (2006). „Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury”. CNS Drug Reviews. 12 (1): 9—20. PMID 16834755. doi:10.1111/j.1527-3458.2006.00009.x.
- ^ Yuan WJ; Yasuhara T; Shingo T; et al. (2008). „Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons”. BMC Neuroscience. 9: 75. PMC 2533664 . PMID 18671880. doi:10.1186/1471-2202-9-75. CS1 одржавање: Експлицитна употреба et al. (веза)
- ^ Kawasaki T; Ishihara K; Ago Y; et al. (2006). „Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum”. European Journal of Pharmacology. 542 (1-3): 92—9. PMID 16784740. doi:10.1016/j.ejphar.2006.05.012. CS1 одржавање: Експлицитна употреба et al. (веза)
- ^ Kawasaki T, Ishihara K, Ago Y, Baba A, Matsuda T (2007). „Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum”. The Journal of Pharmacology and Experimental Therapeutics. 322 (1): 274—81. PMID 17429058. doi:10.1124/jpet.106.119206.
- ^ Yokoyama H, Takagi S, Watanabe Y, Kato H, Araki T (2008). „Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice”. Journal of Neural Transmission (Vienna, Austria : 1996). 115 (6): 831—42. PMID 18235988. doi:10.1007/s00702-008-0019-6.
- ^ Yokoyama H, Yano R, Aoki E, Kato H, Araki T (2008). „Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice”. Metabolic Brain Disease. 23 (3): 335—49. PMID 18648914. doi:10.1007/s11011-008-9096-3.
Literatura
- Doherty, Annette M. (2002). Annual Reports in Medicinal Chemistry, Volume 37 (Annual Reports in Medicinal Chemistry). Boston: Academic Press. ISBN 978-0-12-040537-4.
Spoljašnje veze
- p
- r
- u
- Acetil-L-Karnitin (ALCAR)
- Alfa-lipoinska kiselina (ALA)
- Askorbinska kiselina (Vitamin C)
- Karotenoidi (Vitamin A)
- Kurkumin
- Edaravon
- Flavonoidi (Kvercetin, Kempferol, Katehin, EGCG, itd.)
- Galna kiselina
- Glutation
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- L-Karnitin
- Ladostigil
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- N-Acetilcistein (NAC)
- N-Acetilserotonin (NAS)
- Oleokantal
- Oleuropein
- Polifenol
- Rasagilin
- Resveratrol
- Selegilin
- Selen
- Tokoferoli (Vitamin E)
- Tokotrienoli (Vitamin E)
- Tirozol
- Ubihinon (Koenzime Q)
- Mokraćna kiselina
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