Karnozinska sintaza

Karnozinska sintaza
Identifikatori
EC broj6.3.2.11
CAS broj9023-61-4
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Pretraga
PMCčlanci
PubMedčlanci
NCBIproteini

Karnozinska sintaza (EC 6.3.2.11, karnozinska sintetaza, karnozin-anserinska sintetaza, homokarnozin-karnozinska sintetaza, karnozin-homokarnozinska sintetaza, L-histidin:beta-alanin ligaza (formira AMP)) je enzim sa sistematskim imenom L-histidin:beta-alanin ligaza (formira ADP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-histidin + beta-alanin {\displaystyle \rightleftharpoons } ADP + fosfat + karnozin

Ova enzim formira ADP.

Reference

  1. ^ Kalyankar, G.D. & Meister, A. (1959). „Enzymatic synthesis of carnosine and related β-alanyl and γ-aminobutyryl peptides”. J. Biol. Chem. 234: 3210—3218. PMID 14404206. 
  2. ^ Stenesh, J.J. & Winnick, T. (1960). „Carnosine-anserine synthetase of muscle. 4. Partial purification of the enzyme and further studies of β-alanyl peptide synthesis”. Biochem. J. 77: 575—581. PMID 16748858. 
  3. ^ Crush, K.G. (1970). „Carnosine and related substances in animal tissues”. Comp. Biochem. Physiol. 34: 3—30. PMID 4988625. 
  4. ^ Drozak, J., Veiga-da-Cunha, M., Vertommen, D., Stroobant, V. and Van Schaftingen, E. (2010). „Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)”. J. Biol. Chem. 285: 9346—9356. PMID 20097752. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

  • Carnosine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
  • п
  • р
  • у
Enzimi: CO CS i CN ligaza (EC 6.1-6.3)
6.1: Ugljenik-kiseonik6.2: Ugljenik-sumpor6.3: Ugljenik-azot
  • п
  • р
  • у
Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
Portali:
  •  Molekularna i ćelijska biologija
  •  Hemija