KIAA0174

Protein-coding gene in the species Homo sapiens
IST1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3FRR, 3FRS, 4U7E, 4U7I, 4U7Y, 4WZX, 3JC1

Identifiers
AliasesIST1, OLC1, KIAA0174, ESCRT-III associated factor, CHMP8, IST1 factor associated with ESCRT-III
External IDsOMIM: 616434; MGI: 1919205; HomoloGene: 8849; GeneCards: IST1; OMA:IST1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for IST1
Genomic location for IST1
Band16q22.2Start71,845,996 bp[1]
End71,931,199 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for IST1
Genomic location for IST1
Band8|8 D3Start110,397,957 bp[2]
End110,419,892 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ovary

  • gastric mucosa

  • rectum

  • right ovary

  • right uterine tube

  • skin of leg

  • body of uterus

  • skin of abdomen

  • canal of the cervix

  • anterior pituitary
Top expressed in
  • transitional epithelium of urinary bladder

  • medullary collecting duct

  • vestibular sensory epithelium

  • stroma of bone marrow

  • superior cervical ganglion

  • hair follicle

  • renal corpuscle

  • pyloric antrum

  • gastric mucosa

  • dermis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein domain specific binding
  • protein-containing complex binding
  • protein binding
  • MIT domain binding
  • cadherin binding
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • Flemming body
  • microtubule organizing center
  • extracellular exosome
  • cytoskeleton
  • cytoplasmic vesicle
  • endoplasmic reticulum-Golgi intermediate compartment
  • midbody
  • nuclear envelope
  • nucleus
  • extracellular region
  • azurophil granule lumen
  • intracellular membrane-bounded organelle
  • chromatin
Biological process
  • protein localization
  • viral release from host cell
  • abscission
  • establishment of protein localization
  • viral capsid secondary envelopment
  • multivesicular body assembly
  • cytokinesis
  • positive regulation of collateral sprouting
  • cell division
  • positive regulation of proteolysis
  • protein transport
  • cell cycle
  • ESCRT III complex disassembly
  • neutrophil degranulation
  • cytoskeleton-dependent cytokinesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9798

71955

Ensembl

ENSG00000182149

ENSMUSG00000031729

UniProt

P53990

Q9CX00

RefSeq (mRNA)
NM_014761
NM_001270975
NM_001270976
NM_001270977
NM_001270978

NM_001270979

NM_028018
NM_001361562

RefSeq (protein)
NP_001257904
NP_001257905
NP_001257906
NP_001257907
NP_001257908

NP_055576

NP_082294
NP_001348491

Location (UCSC)Chr 16: 71.85 – 71.93 MbChr 8: 110.4 – 110.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IST1 homolog is a protein that in humans is encoded by the KIAA0174 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182149 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031729 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  6. ^ "Entrez Gene: KIAA0174 KIAA0174".

Further reading

  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–246. doi:10.1006/excr.2000.4948. PMID 10942595.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human IST1 homolog



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