KIAA0430

Protein-coding gene in the species Homo sapiens
MARF1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DGX, 2DIU

Identifiers
AliasesMARF1, LKAP, PPP1R34, KIAA0430, LMKB, meiosis regulator and mRNA stability factor 1
External IDsOMIM: 614593; MGI: 2444505; HomoloGene: 40967; GeneCards: MARF1; OMA:MARF1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for MARF1
Genomic location for MARF1
Band16p13.11Start15,594,387 bp[1]
End15,643,154 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for MARF1
Genomic location for MARF1
Band16|16 A1Start13,927,037 bp[2]
End13,981,215 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • bone marrow cells

  • blood

  • tonsil

  • superior frontal gyrus

  • monocyte

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • gastric mucosa

  • anterior cingulate cortex
Top expressed in
  • zygote

  • aortic valve

  • ascending aorta

  • supraoptic nucleus

  • medial vestibular nucleus

  • mammillary body

  • lateral septal nucleus

  • Rostral migratory stream

  • interventricular septum

  • ventromedial nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA binding
  • nucleic acid binding
  • molecular function
Cellular component
  • peroxisome
  • membrane
  • Golgi apparatus
  • intracellular membrane-bounded organelle
Biological process
  • negative regulation of phosphatase activity
  • regulation of gene expression
  • cell differentiation
  • meiosis
  • female meiotic nuclear division
  • double-strand break repair
  • oogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9665

223989

Ensembl

ENSG00000166783
ENSG00000277140

ENSMUSG00000060657

UniProt

Q9Y4F3

Q8BJ34

RefSeq (mRNA)

NM_001184998
NM_001184999
NM_014647
NM_019081

NM_001081154

RefSeq (protein)

NP_001171927
NP_001171928
NP_055462

NP_001074623

Location (UCSC)Chr 16: 15.59 – 15.64 MbChr 16: 13.93 – 13.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Limkain-b1 is a protein that in humans is encoded by the KIAA0430 gene.[5][6][7][8]

References

  1. ^ a b c ENSG00000277140 GRCh38: Ensembl release 89: ENSG00000166783, ENSG00000277140 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060657 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313. doi:10.1093/dnares/4.5.307. PMID 9455477.
  6. ^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  7. ^ Dunster K, Lai FP, Sentry JW (Jun 2005). "Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes". Clin Exp Immunol. 140 (3): 556–563. doi:10.1111/j.1365-2249.2005.02774.x. PMC 1809386. PMID 15932519.
  8. ^ "Entrez Gene: KIAA0430 KIAA0430".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–994. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Meiosis regulator and mRNA stability factor 1 (KIAA0430)
  • v
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  • e
  • 2dgx: Solution structure of the RNA recognition motif in KIAA0430 protein
    2dgx: Solution structure of the RNA recognition motif in KIAA0430 protein
  • 2diu: Solution structure of the RRM domain of KIAA0430 protein
    2diu: Solution structure of the RRM domain of KIAA0430 protein
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