MCM7

MCM7
Identifikatori
AlijasiMCM7
Spoljašnji IDOMIM: 600592 MGI: 1298398 HomoloGene: 4323 GeneCards: MCM7
Genska lokacija (miš)
Chromosome 5 (mouse)
Hr.Chromosome 5 (mouse)[1]
Chromosome 5 (mouse)
Genomska lokacija za MCM7
Genomska lokacija za MCM7
Band5|5 G2Start138,162,845 bp[1]
Kraj138,170,684 bp[1]
Obrazac RNK izražavanja


More reference expression data
Genska ontologija
Molecular function• nucleotide binding
• GO:0008026 helicase activity
• GO:0004003 DNA helicase activity
• single-stranded DNA binding
• GO:0001948, GO:0016582 везивање за протеине плазме
• hydrolase activity
• ATP binding
• DNA binding
• DNA replication origin binding
• single-stranded 3'-5' DNA helicase activity
Cellular component• мембрана
• Нуклеоплазма
• Хроматин
• MCM complex
• цитосол
• једро
• Једарце
Biological process• cellular response to organic substance
• G1 phase
• cellular response to xenobiotic stimulus
• regulation of phosphorylation
• cellular response to DNA damage stimulus
• cellular response to epidermal growth factor stimulus
• DNA replication initiation
• животни циклус ћелије
• cell population proliferation
• DNA unwinding involved in DNA replication
• репликација ДНК
• G1/S transition of mitotic cell cycle
• double-strand break repair via break-induced replication
• pre-replicative complex assembly involved in nuclear cell cycle DNA replication
• DNA strand elongation involved in DNA replication
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

4176

17220

Ensembl

ENSG00000166508

ENSMUSG00000029730

UniProt

P33993

Q61881

RefSeq (mRNA)

NM_001278595
NM_005916
NM_182776

NM_008568
NM_001356576
NM_001356577

RefSeq (protein)

NP_001265524
NP_005907
NP_877577

NP_032594
NP_001343505
NP_001343506

Location (UCSC)n/aChr 5: 138.16 – 138.17 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Faktor licenciranja DNK replikacije MCM7 je protein koji je kod ljudi kodiran MCM7 genom.[4]

Protein kodiran ovim genom je jedan od visoko konzerviranih proteina mini-hromozomskog održavanja (MCM) koji su esencijalni za inicijaciju replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prireplikacionog kompleksa (pre-RC) i može da učestuje u formiranju replikacionih viljuški i regrutovanju drugih proteina vezanih za DNK replikaciju. MCM kompleks se sastoji od ovog proteina i MCM2, dok 4 i 6 proteini poseduju DNK helikaznu aktivnost, i mogu da deluju kao enzimi DNK odmotavanja. Utvrđeno je da je ciklin D1-zavisna kinaza, CDK4, asocirana sa ovim proteinom, i da može da reguliše vezivanje ovog proteina sa proteinom supresije tumora RB1/RB. Poznate su alternativno splajsovane transkriptne varijante koje kodiraju distinktne izoforme.[5]

Vidi još

Interakcije

MCM7 formira interakcije sa:

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Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000029730 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Nakatsuru S, Sudo K, Nakamura Y (1995). „Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication”. Cytogenet Cell Genet. 68 (3-4): 226—30. PMID 7842741. doi:10.1159/000133918. 
  5. ^ „Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)”. 
  6. ^ а б в г д ђ е ж з и ј к л Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111—28. PMID 12614612. doi:10.1016/s0022-2836(03)00079-2. 
  7. ^ Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha”. Eur. J. Biochem. 265 (3): 936—43. PMID 10518787. doi:10.1046/j.1432-1327.1999.00791.x. 
  8. ^ а б Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation”. J. Biol. Chem. 274 (36): 25927—32. PMID 10464337. doi:10.1074/jbc.274.36.25927. 
  9. ^ а б в г д Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. 272 (16): 10928—35. PMID 9099751. doi:10.1074/jbc.272.16.10928. 
  10. ^ а б в Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (2003). „Mammalian Mcm2/4/6/7 complex forms a toroidal structure”. Genes Cells. 8 (5): 413—21. PMID 12694531. doi:10.1046/j.1365-2443.2003.00645.x. 
  11. ^ а б в You Z, Ishimi Y, Masai H, Hanaoka F (2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. 277 (45): 42471—9. PMID 12207017. doi:10.1074/jbc.M205769200. 
  12. ^ You Z, Komamura Y, Ishimi Y (1999). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. 19 (12): 8003—15. PMC 84885 Слободан приступ. PMID 10567526. 
  13. ^ Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (2002). „Nuclear organization of DNA replication initiation proteins in mammalian cells”. J. Biol. Chem. 277 (12): 10354—61. PMID 11779870. doi:10.1074/jbc.M111398200. 
  14. ^ Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115—22. PMID 8798650. doi:10.1074/jbc.271.39.24115. 
  15. ^ DaFonseca CJ, Shu F, Zhang JJ (2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034—9. PMC 30602 Слободан приступ. PMID 11248027. doi:10.1073/pnas.061487598. 
  16. ^ Wang Y, Xu F, Hall FL (2000). „The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor”. FEBS Lett. 484 (1): 17—21. PMID 11056214. doi:10.1016/s0014-5793(00)02117-7. 
  17. ^ Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (1998). „Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7”. Mol. Cell. Biol. 18 (5): 2748—57. PMC 110654 Слободан приступ. PMID 9566894. doi:10.1128/mcb.18.5.2748. 
  18. ^ Kühne C, Banks L (1998). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box”. J. Biol. Chem. 273 (51): 34302—9. PMID 9852095. doi:10.1074/jbc.273.51.34302. 

Literatura

  • Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (1991). „Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle.”. Biochem. Biophys. Res. Commun. 177 (1): 395—400. PMID 1710453. doi:10.1016/0006-291X(91)91996-P. 
  • Musahl C, Schulte D, Burkhart R, Knippers R (1995). „A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.”. Eur. J. Biochem. 230 (3): 1096—101. PMID 7601140. doi:10.1111/j.1432-1033.1995.tb20660.x. 
  • Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (1994). „The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21.”. Cytogenet. Cell Genet. 65 (4): 276—7. PMID 8258304. doi:10.1159/000133647. 
  • Hu B, Burkhart R, Schulte D, Musahl C, Knippers R (1994). „The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.”. Nucleic Acids Res. 21 (23): 5289—93. PMC 310560 Слободан приступ. PMID 8265339. doi:10.1093/nar/21.23.5289-a. 
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138. 
  • Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1996). „hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase.”. J. Biol. Chem. 271 (8): 4349—54. PMID 8626784. doi:10.1074/jbc.271.8.4349. 
  • Schulte D, Richter A, Burkhart R, Musahl C, Knippers R (1996). „Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins.”. Eur. J. Biochem. 235 (1-2): 144—51. PMID 8631321. doi:10.1111/j.1432-1033.1996.00144.x. 
  • Kiyono T, Fujita M, Hayashi Y, Ishibashi M (1996). „Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family.”. Biochim. Biophys. Acta. 1307 (1): 31—4. PMID 8652665. doi:10.1016/0167-4781(96)00057-7. 
  • Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). „Binding of human minichromosome maintenance proteins with histone H3.”. J. Biol. Chem. 271 (39): 24115—22. PMID 8798650. doi:10.1074/jbc.271.39.24115. 
  • Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.”. J. Biol. Chem. 272 (16): 10928—35. PMID 9099751. doi:10.1074/jbc.272.16.10928. 
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353—8. PMC 139146 Слободан приступ. PMID 9110174. doi:10.1101/gr.7.4.353. 
  • Hiraiwa A, Fujita M, Nagasaka T, Adachi A, Ohashi M, Ishibashi M (1997). „Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth.”. Int. J. Cancer. 74 (2): 180—4. PMID 9133452. doi:10.1002/(SICI)1097-0215(19970422)74:2<180::AID-IJC7>3.0.CO;2-V. 
  • Ishimi Y (1997). „A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.”. J. Biol. Chem. 272 (39): 24508—13. PMID 9305914. doi:10.1074/jbc.272.39.24508. 
  • Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (1998). „Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.”. Mol. Cell. Biol. 18 (5): 2748—57. PMC 110654 Слободан приступ. PMID 9566894. doi:10.1128/mcb.18.5.2748. 
  • Suzuki S, Adachi A, Hiraiwa A, Ohashi M, Ishibashi M, Kiyono T (1998). „Cloning and characterization of human MCM7 promoter.”. Gene. 216 (1): 85—91. PMID 9714754. doi:10.1016/S0378-1119(98)00323-0. 
  • Kühne C, Banks L (1999). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box.”. J. Biol. Chem. 273 (51): 34302—9. PMID 9852095. doi:10.1074/jbc.273.51.34302. 
  • Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.”. J. Biol. Chem. 274 (36): 25927—32. PMID 10464337. doi:10.1074/jbc.274.36.25927. 
  • Freeman A, Morris LS, Mills AD, Stoeber K, Laskey RA, Williams GH, Coleman N (1999). „Minichromosome maintenance proteins as biological markers of dysplasia and malignancy.”. Clin. Cancer Res. 5 (8): 2121—32. PMID 10473096. 
  • Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.”. Eur. J. Biochem. 265 (3): 936—43. PMID 10518787. doi:10.1046/j.1432-1327.1999.00791.x. 
  • p
  • r
  • u
Separacija
i inicijacija
Prokariotska
(inicijacija)
Eukariotska
(priprema u
G1 fazi)
Oba
Replikacija
Prokariotska
(elongacija)
Eukariotska
(sinteza u
S fazi)
Oba
Kretanje: Procesivnost · DNK ligaza
Terminacija
B bsyn: dnk (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)