RFC1

RFC1
Available structures
PDBPretraga ortologa: PDBe RCSB
List of PDB id codes

2EBU, 2K6G, 2K7F

Identifikatori
AlijasiRFC1
Spoljašnji IDOMIM: 102579 MGI: 97891 HomoloGene: 2187 GeneCards: RFC1
Genska lokacija (miš)
Chromosome 5 (mouse)
Hr.Chromosome 5 (mouse)[1]
Chromosome 5 (mouse)
Genomska lokacija za RFC1
Genomska lokacija za RFC1
Band5 C3.1|5 33.61 cMStart65,419,193 bp[1]
Kraj65,493,013 bp[1]
Obrazac RNK izražavanja


More reference expression data
Genska ontologija
Molecular function• nucleotide binding
• GO:0001948, GO:0016582 везивање за протеине плазме
• GO:0010577 enzyme activator activity
• ATP binding
• DNA clamp loader activity
• DNA binding
• sequence-specific DNA binding
• double-stranded DNA binding
• protein domain specific binding
• DNA clamp unloader activity
Cellular component• Нуклеоплазма
• extracellular exosome
• Replikacioni faktor C
• једро
• Једарце
• цитоплазма
• Elg1 RFC-like complex
• GO:0009327 макромолекуларни комплекс
Biological process• DNA-dependent DNA replication
• nucleotide-excision repair, DNA gap filling
• GO:0009373 regulation of transcription, DNA-templated
• telomere maintenance via telomerase
• error-free translesion synthesis
• transcription, DNA-templated
• error-prone translesion synthesis
• репликација ДНК
• translesion synthesis
• transcription-coupled nucleotide-excision repair
• nucleotide-excision repair, DNA incision
• GO:0100026 поправка ДНК
• nucleotide-excision repair, DNA incision, 5'-to lesion
• GO:0048554 positive regulation of catalytic activity
• GO:1901227 negative regulation of transcription by RNA polymerase II
• GO:0045996 negative regulation of transcription, DNA-templated
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• telomere maintenance via semi-conservative replication
• DNA clamp unloading
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

5981

19687

Ensembl

ENSG00000035928

ENSMUSG00000029191

UniProt

P35251

P35601

RefSeq (mRNA)

NM_001204747
NM_002913
NM_001363495
NM_001363496

NM_011258
NM_001347357
NM_001347358

RefSeq (protein)

NP_001191676
NP_002904
NP_001350424
NP_001350425

NP_001334286
NP_001334287
NP_035388

Location (UCSC)n/aChr 5: 65.42 – 65.49 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Replikacioni faktor C, podjednica 1 je protein koji je kod ljudi kodiran RFC1 genom.[4][5]

Protein kodiran ovim genom je velika podjedinica replikacionog faktora C, koji je pomoćni protein DNK polimeraze sa pet podjedinica. Replikacioni faktor C je od DNK zavisna ATPaza koja je neophodna za eukariotsku DNK replikaciju i popravku. Protein deluje kao aktivator DNK polimeraza, putem vezivanja za 3' kraj prajmera, i promoviše koordiniranu sintezu oba lanca. On takođe doprinosi stabilnosti telomera.[5]

Interakcije

RFC1 formira interakcije sa:

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000029191 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (1994). „Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans”. Mol Cell Biol. 14 (3): 1626—34. PMC 358521 Слободан приступ. PMID 8114700. 
  5. ^ а б „Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa”. 
  6. ^ а б Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 Слободан приступ. PMID 12192049. doi:10.1128/mcb.22.18.6509-6520.2002. 
  7. ^ Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. PMID 12045192. doi:10.1074/jbc.M200513200. 
  8. ^ Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. 15 (16): 4423—33. PMC 452166 Слободан приступ. PMID 8861969. 
  9. ^ Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. PMID 8999859. doi:10.1074/jbc.272.3.1769. 
  10. ^ van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365. 
  11. ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 
  12. ^ Anderson LA, Perkins ND (2003). „Regulation of RelA (p65) function by the large subunit of replication factor C”. Mol. Cell. Biol. 23 (2): 721—32. PMC 151544 Слободан приступ. PMID 12509469. doi:10.1128/mcb.23.2.721-732.2003. 
  13. ^ Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979. 
  14. ^ Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056 Слободан приступ. PMID 8692848. doi:10.1073/pnas.93.13.6521. 
  15. ^ Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T (2008). „DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex”. J. Biol. Chem. 283 (14): 9071—9. PMC 2431014 Слободан приступ. PMID 18245774. doi:10.1074/jbc.M709835200. 

Literatura

  • Lu Y, Riegel AT (1994). „The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA”. Gene. 145 (2): 261—5. PMID 7914507. doi:10.1016/0378-1119(94)90017-5. 
  • Bunz F, Kobayashi R, Stillman B (1994). „cDNAs encoding the large subunit of human replication factor C”. Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11014—8. PMC 47912 Слободан приступ. PMID 8248204. doi:10.1073/pnas.90.23.11014. 
  • Lu Y, Zeft AS, Riegel AT (1993). „Cloning and expression of a novel human DNA binding protein, PO-GA”. Biochem. Biophys. Res. Commun. 193 (2): 779—86. PMID 8512577. doi:10.1006/bbrc.1993.1693. 
  • Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056 Слободан приступ. PMID 8692848. doi:10.1073/pnas.93.13.6521. 
  • Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. 15 (16): 4423—33. PMC 452166 Слободан приступ. PMID 8861969. 
  • Uchiumi F, Ohta T, Tanuma S (1997). „Replication factor C recognizes 5'-phosphate ends of telomeres”. Biochem. Biophys. Res. Commun. 229 (1): 310—5. PMID 8954124. doi:10.1006/bbrc.1996.1798. 
  • Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. PMID 8999859. doi:10.1074/jbc.272.3.1769. 
  • Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol. 17 (4): 1817—23. PMC 232028 Слободан приступ. PMID 9121429. 
  • Ubeda M, Habener JF (1997). „The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis”. J. Biol. Chem. 272 (31): 19562—8. PMID 9235961. doi:10.1074/jbc.272.31.19562. 
  • Rhéaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, Sékaly RP, Denis F (1998). „The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis”. EMBO J. 16 (21): 6346—54. PMC 1170241 Слободан приступ. PMID 9351817. doi:10.1093/emboj/16.21.6346. 
  • Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979. 
  • Coll JM, Hickey RJ, Cronkey EA, Jiang HY, Schnaper L, Lee MY, Uitto L, Syvaoja JE, Malkas LH (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11–12): 629—39. PMID 9563011. 
  • Allen BL, Uhlmann F, Gaur LK, Mulder BA, Posey KL, Jones LB, Hardin SH (1998). „DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C”. Nucleic Acids Res. 26 (17): 3877—82. PMC 147807 Слободан приступ. PMID 9705493. doi:10.1093/nar/26.17.3877. 
  • van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365. 
  • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (2000). „BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures”. Genes Dev. 14 (8): 927—39. PMC 316544 Слободан приступ. PMID 10783165. doi:10.1101/gad.14.8.927. 
  • Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J (2002). „SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint”. Genes Dev. 16 (5): 571—82. PMC 155356 Слободан приступ. PMID 11877377. doi:10.1101/gad.970702. 
  • Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. PMID 12045192. doi:10.1074/jbc.M200513200. 
  • Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 
  • Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 Слободан приступ. PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002. 
  • p
  • r
  • u
Separacija
i inicijacija
Prokariotska
(inicijacija)
Eukariotska
(priprema u
G1 fazi)
Oba
Replikacija
Prokariotska
(elongacija)
Eukariotska
(sinteza u
S fazi)
Oba
Kretanje: Procesivnost · DNK ligaza
Terminacija
B bsyn: dnk (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)