POLD2

Available structures

PDB

Pretraga ortologa: PDBe RCSB

List of PDB id codes
3E0J

Identifikatori

Alijasi

POLD2

Spoljašnji ID

OMIM: 600815 MGI: 1097163 HomoloGene: 4538 GeneCards: POLD2

Genska lokacija (miš)

Hr.	Chromosome 11 (mouse)^[1]

Band	11\|11 A1	Start	5,822,180 bp^[1]
Band	11\|11 A1	Kraj	5,828,292 bp^[1]

Obrazac RNK izražavanja

More reference expression data

Genska ontologija
Molecular function	• DNA binding • GO:0001948, GO:0016582 везивање за протеине плазме • DNA-directed DNA polymerase activity
Cellular component	• Нуклеоплазма • једро • delta DNA polymerase complex
Biological process	• nucleotide-excision repair, DNA gap filling • репликација ДНК • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • telomere maintenance • nucleotide-excision repair, DNA incision, 5'-to lesion • GO:0100026 поправка ДНК • DNA strand elongation involved in DNA replication • cellular response to DNA damage stimulus • telomere maintenance via semi-conservative replication • DNA mismatch repair • DNA biosynthetic process
Sources:Amigo / QuickGO

Ortolozi

Vrste

Čovek

Miš

Entrez


5425


18972

Ensembl


ENSG00000106628


ENSMUSG00000020471

UniProt


P49005


O35654

RefSeq (mRNA)


NM_001127218 NM_001256879 NM_006230


NM_008894 NM_001361942

RefSeq (protein)


NP_001120690 NP_001243808 NP_006221


NP_032920 NP_001348871

Location (UCSC)

n/a

Chr 11: 5.82 – 5.83 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Delta podjedinica 2 DNK polimeraze je enzim koji je kod ljudi kodiran POLD2 genom.^[4]^[5] On je komponenta kompleksa DNK polimeraze delta.

Interakcije

OLD2 formira interakcije sa PCNA.^[6]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000020471 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang J, Tan CK, McMullen B, Downey KM, So AG (1996). „Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)”. Genomics. 29 (1): 179—86. PMID 8530069. doi:10.1006/geno.1995.1229.
^ „Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa”.
^ Lu, Xiaoqing; Tan Cheng-Keat; Zhou Jin-Qiu; You Min; Carastro L Michael; Downey Kathleen M; So Antero G (2002). „Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta”. J. Biol. Chem. United States. 277 (27): 24340—5. ISSN 0021-9258. PMID 11986310. doi:10.1074/jbc.M200065200.

Literatura

Hindges R, Hübscher U (1997). „Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).”. Genomics. 44 (1): 45—51. PMID 9286699. doi:10.1006/geno.1997.4838.
Hisama FM, Chen YH, Meyn MS, et al. (2000). „WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts”. Cancer Res. 60 (9): 2372—6. PMID 10811112.
Mo J, Liu L, Leon A, et al. (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA”. Biochemistry. 39 (24): 7245—54. PMID 10852724. doi:10.1021/bi0000871.
Perez A, Leon A, Lee MY (2000). „Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta”. Biochim. Biophys. Acta. 1493 (1–2): 231—6. PMID 10978529. doi:10.1016/s0167-4781(00)00153-6.
Szekely AM, Chen YH, Zhang C, et al. (2000). „Werner protein recruits DNA polymerase δ to the nucleolus”. Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365—70. PMC 17206 . PMID 11027336. doi:10.1073/pnas.97.21.11365.
He H, Tan CK, Downey KM, So AG (2001). „A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen”. Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979—84. PMC 59753 . PMID 11593007. doi:10.1073/pnas.221452098.
Lu X, Tan CK, Zhou JQ, et al. (2002). „Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta”. J. Biol. Chem. 277 (27): 24340—5. PMID 11986310. doi:10.1074/jbc.M200065200.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Liu L, Rodriguez-Belmonte EM, Mazloum N, et al. (2003). „Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen”. J. Biol. Chem. 278 (12): 10041—7. PMID 12522211. doi:10.1074/jbc.M208694200.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human Chromosome 7: DNA Sequence and Biology”. Science. 300 (5620): 767—72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Lehner B, Sanderson CM (2004). „A Protein Interaction Framework for Human mRNA Degradation”. Genome Res. 14 (7): 1315—23. PMC 442147 . PMID 15231747. doi:10.1101/gr.2122004.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Tsurimoto T, Shinozaki A, Yano M, et al. (2005). „Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta”. Genes Cells. 10 (1): 13—22. PMID 15670210. doi:10.1111/j.1365-2443.2004.00812.x.
Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.

DNK replikacija (Prokariotska, Eukariotska)

Separacija
i inicijacija

Prokariotska (inicijacija)	Prereplikacioni kompleks Cdc6 Helikaza (dnaA, dnaB, T7) · Primaza (dnaG)
Eukariotska (priprema u G1 fazi)	Prereplikacioni kompleks: Kompleks prepoznavanja mesta početka (ORC1, ORC2, ORC3, ORC4, ORC5, ORC6) · Održavanje minihromozoma (MCM2 · MCM3 · MCM4 · MCM5 · MCM6 · MCM7) · CDC6 Faktor licenciranja Autonomna replikaciona sekvenca Protein jednolančanog vezivanja (SSBP1, SSBP2, SSBP3, SSBP4) RNaza H (RNASEH1, RNASEH2A) Helikaza: HFM1 Primaza: PRIM1 · PRIM2
Oba	Početak replikacije/Ori/Replikon Replikaciona viljuška (zaostajući i vodeći lanci) · Okazakijev fragment · Prajmer

Replikacija

Prokariotska (elongacija)	DNK polimeraza III holoenzim (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX, holA, holB, holC, holD, holE) · Replizom · DNK ligaza · DNK stega · Topoizomeraza (DNK giraza) Prokariotska DNK polimeraza: DNK polimeraza I (Klenov fragment)
Eukariotska (sinteza u S fazi)	Replikacioni faktor C (RFC1) · Endonukleaza prepusta (FEN1) · Topoizomeraza · Replikacioni protein A (RPA1) Eukariotska DNK polimeraza: delta (POLD1, POLD2, POLD3, POLD4) DNK stega (PCNA)
Oba	Kretanje: Procesivnost · DNK ligaza

Terminacija

Telomer: Telomeraza (TERT, TERC, DKC1)

B bsyn: dnk (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)