SIRPA |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2JJS, 2JJT, 2UV3, 2WNG, 4CMM | | |
Ідентифікатори |
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Символи | SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, Signal-regulatory protein alpha, signal regulatory protein alpha |
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Зовнішні ІД | OMIM: 602461 MGI: 108563 HomoloGene: 7246 GeneCards: SIRPA |
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Онтологія гена |
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Молекулярна функція | • SH3 domain binding • protein phosphatase binding • GO:0005083 GTPase regulator activity • protein binding involved in heterotypic cell-cell adhesion • cell-cell adhesion mediator activity • protein antigen binding • protein tyrosine kinase binding |
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Клітинна компонента | • integral component of membrane • клітинна мембрана • екзосома • мембрана • tertiary granule membrane • ficolin-1-rich granule membrane • integral component of plasma membrane • cell surface |
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Біологічний процес | • адгезія клітин • leukocyte migration • neutrophil degranulation • GO:0033128 negative regulation of protein phosphorylation • регуляція експресії генів • cell migration • positive regulation of cell-cell adhesion • regulation of interferon-gamma production • regulation of interleukin-1 beta production • regulation of interleukin-6 production • regulation of tumor necrosis factor production • negative regulation of interferon-beta production • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production • heterotypic cell-cell adhesion • monocyte extravasation • negative regulation of nitric oxide biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of JNK cascade • negative regulation of inflammatory response • negative regulation of phagocytosis • positive regulation of phagocytosis • GO:0048552 regulation of catalytic activity • positive regulation of T cell activation • cellular response to hydrogen peroxide • negative regulation of ERK1 and ERK2 cascade • cellular response to lipopolysaccharide • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to interleukin-12 • negative regulation of macrophage inflammatory protein 1 alpha production • negative regulation of chemokine (C-C motif) ligand 5 production • cell-cell adhesion • negative regulation of cytokine production involved in inflammatory response • negative regulation of I-kappaB phosphorylation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001040022 NM_001040023 NM_080792 NM_001330728 |
| NM_001177646 NM_001177647 NM_001291019 NM_001291020 NM_001291021
| NM_001291022 NM_007547 NM_001355158 NM_001355160 |
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RefSeq (білок) | | NP_001035111 NP_001035112 NP_001317657 NP_542970 |
| NP_001171118 NP_001277948 NP_001277949 NP_001277950 NP_001277951
| NP_031573 NP_001342087 NP_001342089 |
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Локус (UCSC) | Хр. 20: 1.89 – 1.94 Mb | Хр. 2: 129.43 – 129.47 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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